Immunology was founded by studying the body's response to infectious microorganisms,
and yet microbial prokaryotes only tell half the story of the immune system. Eukaryotic …

… to NES; mice deficient in the IL-4R are able to mount an IL-4 response in the CD4 + population,
arguing that other signals are sufficient for Th2 differentiation to begin (Balic and Maizels, …

The vertebrate immune system has evolved in concert with a broad range of infectious
agents, including ubiquitous helminth (worm) parasites. The constant pressure of helminth …

Helminths are masterful immunoregulators. A characteristic feature of helminth infection is a
Th2-dominated immune response, but stimulation of immunoregulatory cell populations, …

Helminth parasitic infections are a major global health and social burden 1 . The host
defence against helminths such as Nippostrongylus brasiliensis is orchestrated by type 2 cell-…

… Taylor, Adam Balic, Constance AM Finney, Jonathan R. Lamb, Rick M. Maizels; Suppression
of allergic airway inflammation by helminth-induced regulatory T cells . J Exp Med 7 …

… Rates of reinfection reflect the magnitude of the basic reproductive rate, R, , a measure of
the average number of offspring produced by one female worm (in the case of dioecious …

In mammalian systems RNA can move between cells via vesicles. Here we demonstrate that
the gastrointestinal nematode Heligmosomoides polygyrus, which infects mice, secretes …

Helminth parasites infect almost one-third of the world's population, primarily in tropical
regions. However, regions where helminth parasites are endemic record much lower …

Foxp3-expressing regulatory T (T reg) cells have been implicated in parasite-driven inhibition
of host immunity during chronic infection. We addressed whether parasites can directly …