User profiles for R. Matthew Hutchison

R. Matthew Hutchison

Associate Director, Biomarkers, Biogen
Verified email at biogen.com
Cited by 7088

Dynamic functional connectivity: promise, issues, and interpretations

RM Hutchison, T Womelsdorf, EA Allen, PA Bandettini… - Neuroimage, 2013 - Elsevier
The brain must dynamically integrate, coordinate, and respond to internal and external stimuli
across multiple time scales. Non-invasive measurements of brain activity with fMRI have …

Resting‐state networks show dynamic functional connectivity in awake humans and anesthetized macaques

RM Hutchison, T Womelsdorf, JS Gati… - Human brain …, 2013 - Wiley Online Library
Characterization of large‐scale brain networks using blood‐oxygenation‐level‐dependent
functional magnetic resonance imaging is typically based on the assumption of network …

[HTML][HTML] Trial of cinpanemab in early Parkinson's disease

…, I Sapir, J Inra, RM Hutchison… - … England Journal of …, 2022 - Mass Medical Soc
Background Aggregated α-synuclein plays an important role in Parkinson’s disease
pathogenesis. Cinpanemab, a human-derived monoclonal antibody that binds to α-synuclein, is …

Dynamic brain network correlates of spontaneous fluctuations in attention

A Kucyi, MJ Hove, M Esterman, RM Hutchison… - Cerebral …, 2017 - academic.oup.com
Human attention is intrinsically dynamic, with focus continuously shifting between elements
of the external world and internal, self-generated thoughts. Communication within and …

Tracking the brain's functional coupling dynamics over development

RM Hutchison, JB Morton - Journal of Neuroscience, 2015 - Soc Neuroscience
The transition from childhood to adulthood is marked by pronounced functional and
structural brain transformations that impact cognition and behavior. Here, we use a functional …

Functional networks in the anesthetized rat brain revealed by independent component analysis of resting-state FMRI

RM Hutchison, SM Mirsattari… - Journal of …, 2010 - journals.physiology.org
The rodent brain is organized into functional networks that can be studied through
examination of synchronized low-frequency spontaneous fluctuations (LFFs) of the functional …

Network structure shapes spontaneous functional connectivity dynamics

K Shen, RM Hutchison, G Bezgin… - Journal of …, 2015 - Soc Neuroscience
The structural organization of the brain constrains the range of interactions between different
regions and shapes ongoing information processing. Therefore, it is expected that large-…

Dwelling quietly in the rich club: brain network determinants of slow cortical fluctuations

LL Gollo, A Zalesky, RM Hutchison… - … of the Royal …, 2015 - royalsocietypublishing.org
For more than a century, cerebral cartography has been driven by investigations of
structural and morphological properties of the brain across spatial scales and the temporal/functional …

Identification of optimal structural connectivity using functional connectivity and neural modeling

…, AR McIntosh, K Shen, RM Hutchison… - Journal of …, 2014 - Soc Neuroscience
The complex network dynamics that arise from the interaction of the brain's structural and
functional architectures give rise to mental function. Theoretical models demonstrate that the …

Isoflurane induces dose‐dependent alterations in the cortical connectivity profiles and dynamic properties of the brain's functional architecture

RM Hutchison, M Hutchison, KY Manning… - Human brain …, 2014 - Wiley Online Library
Despite their widespread use, the effect of anesthetic agents on the brain's functional architecture
remains poorly understood. This is particularly true of alterations that occur beyond the …