User profiles for R. Matthew Hutchison
R. Matthew HutchisonAssociate Director, Biomarkers, Biogen Verified email at biogen.com Cited by 7088 |
Dynamic functional connectivity: promise, issues, and interpretations
The brain must dynamically integrate, coordinate, and respond to internal and external stimuli
across multiple time scales. Non-invasive measurements of brain activity with fMRI have …
across multiple time scales. Non-invasive measurements of brain activity with fMRI have …
Resting‐state networks show dynamic functional connectivity in awake humans and anesthetized macaques
Characterization of large‐scale brain networks using blood‐oxygenation‐level‐dependent
functional magnetic resonance imaging is typically based on the assumption of network …
functional magnetic resonance imaging is typically based on the assumption of network …
[HTML][HTML] Trial of cinpanemab in early Parkinson's disease
…, I Sapir, J Inra, RM Hutchison… - … England Journal of …, 2022 - Mass Medical Soc
Background Aggregated α-synuclein plays an important role in Parkinson’s disease
pathogenesis. Cinpanemab, a human-derived monoclonal antibody that binds to α-synuclein, is …
pathogenesis. Cinpanemab, a human-derived monoclonal antibody that binds to α-synuclein, is …
Dynamic brain network correlates of spontaneous fluctuations in attention
Human attention is intrinsically dynamic, with focus continuously shifting between elements
of the external world and internal, self-generated thoughts. Communication within and …
of the external world and internal, self-generated thoughts. Communication within and …
Tracking the brain's functional coupling dynamics over development
RM Hutchison, JB Morton - Journal of Neuroscience, 2015 - Soc Neuroscience
The transition from childhood to adulthood is marked by pronounced functional and
structural brain transformations that impact cognition and behavior. Here, we use a functional …
structural brain transformations that impact cognition and behavior. Here, we use a functional …
Functional networks in the anesthetized rat brain revealed by independent component analysis of resting-state FMRI
RM Hutchison, SM Mirsattari… - Journal of …, 2010 - journals.physiology.org
The rodent brain is organized into functional networks that can be studied through
examination of synchronized low-frequency spontaneous fluctuations (LFFs) of the functional …
examination of synchronized low-frequency spontaneous fluctuations (LFFs) of the functional …
Network structure shapes spontaneous functional connectivity dynamics
The structural organization of the brain constrains the range of interactions between different
regions and shapes ongoing information processing. Therefore, it is expected that large-…
regions and shapes ongoing information processing. Therefore, it is expected that large-…
Dwelling quietly in the rich club: brain network determinants of slow cortical fluctuations
For more than a century, cerebral cartography has been driven by investigations of
structural and morphological properties of the brain across spatial scales and the temporal/functional …
structural and morphological properties of the brain across spatial scales and the temporal/functional …
Identification of optimal structural connectivity using functional connectivity and neural modeling
The complex network dynamics that arise from the interaction of the brain's structural and
functional architectures give rise to mental function. Theoretical models demonstrate that the …
functional architectures give rise to mental function. Theoretical models demonstrate that the …
Isoflurane induces dose‐dependent alterations in the cortical connectivity profiles and dynamic properties of the brain's functional architecture
Despite their widespread use, the effect of anesthetic agents on the brain's functional architecture
remains poorly understood. This is particularly true of alterations that occur beyond the …
remains poorly understood. This is particularly true of alterations that occur beyond the …