As people age they become increasingly susceptible to chronic and extremely debilitating
brain diseases. The precise cause of the neuronal degeneration underlying these disorders, …

After years of failed attempts to develop a disease-modifying therapy for Alzheimer’s disease,
consistent evidence in support of clinical efficacy was finally presented for a monoclonal …

The pathological processes leading to synapse loss, neuronal loss, brain atrophy and
gliosis in Alzheimer's disease (AD) and their relation to vascular disease and immunological …

This multicenter study examined 18 F-FDG PET measures in the differential diagnosis of
Alzheimer's disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB…

Objective Although the clinical course of Alzheimer disease (AD) is gradual, it is useful for a
number of reasons to distinguish between different levels of severity. The Clinical Dementia …

Background Frontotemporal dementia (FTD) is a complex disorder characterised by a broad
range of clinical manifestations, differential pathological signatures, and genetic variability. …

We assessed the geographical distribution of C9orf72 G 4 C 2 expansions in a pan‐ E
uropean frontotemporal lobar degeneration ( FTLD ) cohort (n = 1,205), ascertained by the E …

Introduction Progress in understanding and management of vascular cognitive impairment (VCI)
has been hampered by lack of consensus on diagnosis, reflecting the use of multiple …

Neurochemical dementia diagnostics (NDD) can significantly improve the clinically based
categorization of patients with early dementia disorders, and the cerebrospinal fluid (CSF) …

… negative correlation of the above-mentioned scales in MCI patients (r = −0.46, P<0.01). Both
… B-ADL and ADCS-MCI-ADL scores were also significantly correlated in patients (r = –0.61, P…