[HTML][HTML] E-cigarette affects the metabolome of primary normal human bronchial epithelial cells
… All statistical analyses were performed with R version 2.14.0 (The … that of histidine (S1A
Fig) (R = 0.91, p<0.001), as did the level of glutamate with that of glutamine (R = 0.8; p<0.001). …
Fig) (R = 0.91, p<0.001), as did the level of glutamate with that of glutamine (R = 0.8; p<0.001). …
[HTML][HTML] Inhibition of MAP4K4 signaling initiates metabolic reprogramming to protect hepatocytes from lipotoxic damage
…, E Cansby, S Kumari, M Henricsson, R Porosk… - Journal of Lipid …, 2022 - ASBMB
The primary hepatic consequence of obesity is non-alcoholic fatty liver disease (NAFLD),
affecting about 25% of the global adult population. Non-alcoholic steatohepatitis (NASH) is a …
affecting about 25% of the global adult population. Non-alcoholic steatohepatitis (NASH) is a …
[HTML][HTML] Silencing of STE20-type kinase TAOK1 confers protection against hepatocellular lipotoxicity through metabolic rewiring
…, E Cansby, M Caputo, S Kumari, R Porosk… - Hepatology …, 2023 - journals.lww.com
Background: NAFLD has become the leading cause of chronic liver disease worldwide afflicting
about one quarter of the adult population. NASH is a severe subtype of NAFLD, which in …
about one quarter of the adult population. NASH is a severe subtype of NAFLD, which in …
[HTML][HTML] Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease
…, A Nerstedt, M Ståhlman, J Borén, R Porosk… - JCI insight, 2020 - ncbi.nlm.nih.gov
Diabetic kidney disease (DKD) is the most common cause of severe renal disease worldwide
and the single strongest predictor of mortality in diabetes patients. Kidney steatosis has …
and the single strongest predictor of mortality in diabetes patients. Kidney steatosis has …
[HTML][HTML] Hypothermia augments stress response in mammalian cells
KL Eskla, R Porosk, R Reimets, T Visnapuu… - Free Radical Biology …, 2018 - Elsevier
Mild hypothermia (32 C) is routinely used in medical practice to alleviate hypoxic ischemic
damage, however, the mechanisms that underlie its protective effects remain uncertain. Using …
damage, however, the mechanisms that underlie its protective effects remain uncertain. Using …
On the methodological limitations of detecting oxidative stress: effects of paraquat on measures of oxidative status in greenfinches
… Body mass was the single parameter showing significant repeatability between blood
sampling events in the pooled data (R=0.64, F 28,29 =4.5, P<0.0001), as well as in the control (R=…
sampling events in the pooled data (R=0.64, F 28,29 =4.5, P<0.0001), as well as in the control (R=…
[HTML][HTML] Hypothermia alleviates reductive stress, a root cause of ischemia reperfusion injury
…, L Tarve, H Eichelmann, T Jagomäe, R Porosk… - International Journal of …, 2022 - mdpi.com
… = v(C o − C i ), where C with subscripts denote concentrations, mole/mole −1 (fractional, i
at the inlet and o at the outlet), v is the gas flow rate, mole s −1 , and respiration rate R is …
at the inlet and o at the outlet), v is the gas flow rate, mole s −1 , and respiration rate R is …
[HTML][HTML] STE20-type kinase TAOK3 regulates hepatic lipid partitioning
…, SK Anand, S Sütt, M Henricsson, R Porosk… - Molecular …, 2021 - Elsevier
Objective Nonalcoholic fatty liver disease (NAFLD), defined by excessive lipid storage in
hepatocytes, has recently emerged as a leading global cause of chronic liver disease. The aim …
hepatocytes, has recently emerged as a leading global cause of chronic liver disease. The aim …
Metabolomics of the Wolfram Syndrome 1 Gene (Wfs1) Deficient Mice
R Porosk, A Terasmaa, R Mahlapuu… - OMICS: A Journal of …, 2017 - liebertpub.com
Wolfram syndrome 1 is a rare autosomal recessive neurodegenerative disease characterized
by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. Mutations in the …
by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. Mutations in the …
[HTML][HTML] Silencing of STE20-type kinase STK25 in human aortic endothelial and smooth muscle cells is atheroprotective
E Cansby, S Kumari, M Caputo, Y Xia, R Porosk… - Communications …, 2022 - nature.com
Recent studies highlight the importance of lipotoxic damage in aortic cells as the major
pathogenetic contributor to atherosclerotic disease. Since the STE20-type kinase STK25 has …
pathogenetic contributor to atherosclerotic disease. Since the STE20-type kinase STK25 has …