Background The genetic alterations responsible for an adverse outcome in most patients
with acute myeloid leukemia (AML) are unknown. Methods Using massively parallel DNA …

Somatic mutations have been extensively characterized in breast cancer, but the effects of
these genetic alterations on the proteomic landscape remain poorly understood. Here we …

Extensive genomic characterization of human cancers presents the problem of inference
from genomic abnormalities to cancer phenotypes. To address this problem, we analysed …

Intracellular nicotinamide phosphoribosyltransferase (iNampt) is an essential enzyme in the
NAD biosynthetic pathway. An extracellular form of this protein (eNampt) has been reported …

To provide a detailed analysis of the molecular components and underlying mechanisms
associated with ovarian cancer, we performed a comprehensive mass-spectrometry-based …

Adoption of targeted mass spectrometry (MS) approaches such as multiple reaction monitoring
(MRM) to study biological and biomedical questions is well underway in the proteomics …

We performed the first proteogenomic study on a prospectively collected colon cancer cohort.
Comparative proteomic and phosphoproteomic analysis of paired tumor and normal …

The method of anion exchange chromatography followed by pulsed amperometric detection
(AE-PAD; Johnson, DC, and Polta, TZ (1986) Chromatogr. Forum1, 37–44) has been …

BACKGROUND: Disease-modifying therapies for Alzheimer's disease (AD) would be most
effective during the preclinical stage (pathology present, cognition intact) before significant …

Somatic mutations in DNMT3A, which encodes a de novo DNA methyltransferase, are found
in ∼30% of normal karyotype acute myeloid leukemia (AML) cases. Most mutations are …