WNTs are lipid-modified proteins that control multiple functions in development and disease
via short- and long-range signaling. However, it is unclear how these hydrophobic …

… R. Sedláček was supported by grants funded by the Ministry of Education, Youth, and
Sports (LM2015040, CZ.1.05/2.1.00/19.0395, and LQ1604) and the European Regional …

The development of thymic regulatory T cells (Treg) is mediated by Aire-regulated self-antigen
presentation on medullary thymic epithelial cells (mTECs) and dendritic cells (DCs), but …

Late aseptic loosening of cemented acetabular components is governed by the progressive,
three-dimensional resorption of the bone immediately adjacent to the cement mantle. This …

The novel CXC-chemokine ligand 16 (CXCL16) functions as transmembrane adhesion
molecule on the surface of APCs and as a soluble chemoattractant for activated T cells. In this …

Alcohol use has been identified as a risk factor for the development of osteoporosis. Eight
male Wistar rats at two months of age were alcoho-fed (7.6 g 95% ethanol/kg bw per day) to …

This study aims to point out the main drawback with respect to the design of simulated body
environments. Three media commonly used for the simulation of the identical body …

Imprinting diseases (IDs) are rare congenital disorders caused by aberrant dosages of
imprinted genes. Rare IDs are comprised by a group of several distinct disorders that share a …

The aim of the study was to develop an orthopedic implant coating in the form of vancomycin-loaded
collagen/hydroxyapatite layers (COLHA+V) that combine the ability to prevent bone …

Evolution equations for scalar density and orientation of fields of curved dislocations formulated
in the framework of the continuum theory of moving dislocations serve as the starting …