There is still an unresolved paradox with respect to the immunomodulating role of estrogens.
On one side, we recognize inhibition of bone resorption and suppression of inflammation in …

Sex hormones seem to play an important role as modulators of the autoimmune disease
onset/perpetuation. Generally, steroid hormones are implicated in the immune response, with …

Methotrexate (MTX) is a folate analogue originally synthesised in the 1940s and designed
to inhibit dihydrofolate reductase. 1 Reduced folate (tetrahydrofolate) is the proximal single …

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

Abnormalities of prefrontal cortical function are prominent features of schizophrenia and have
been associated with genetic risk, suggesting that susceptibility genes for schizophrenia …

Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to
siblings of probands. Replication has been inconsistent for reports of significant genetic …

Intelligence is highly heritable 1 and a major determinant of human health and well-being 2
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …

A map of 191 single-nucleotide polymorphism (SNPs) was built across a 5-Mb segment
from chromosome 13q34 that has been genetically linked to schizophrenia. DNA from 213 …

A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts
variation in human memory, and is associated with several neurological and psychiatric …

Prior evidence has supported the existence of multiple susceptibility genes for schizophrenia.
Multipoint linkage analysis of the 270 Irish high-density pedigrees that we have studied, as …