The C. elegans HIF-1 proline hydroxylase EGL-9 functions as an O 2 sensor in an evolutionarily
conserved pathway for adaptation to hypoxia. H 2 S accumulates during hypoxia and …

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)
protein that can be secreted and protects dopamine neurons and cardiomyocytes from …

Hydrogen sulfide (H2S), long viewed as a toxic gas and environmental hazard, is emerging
as a biological mediator with remarkable physiological and pathophysiological relevance. …

Idiopathic Parkinson’s disease (PD) is characterized by progressive loss of dopaminergic
neurons during aging. The pathological hallmark of PD is the Lewy body detected in …

Parkinson’s disease (PD) is associated with various deficits in sensing and responding to
reductions in oxygen availability (hypoxia). Here we summarize the evidence pointing to a …

… Roman Vozdek designed and performed most of the experiments and wrote the first draft
of the paper; Aleš Hnízda purified and further characterized recombinant CBS-1; Jakub Krijt …

… Using the model organism Caenorhabditis elegans, Vozdek et al. searched for pathways
involved in coping with hypoxic environments and identified a receptor tyrosine kinase that they …

… Spearman's rank correlation coefficient shows a significant correlation (r s … 5 show a very
good correlation between plasma homolanthionine and total homocysteine (Spearman's r s …

O-Acetylserine(thiol)lyases (OAS-TLs) play a pivotal role in a sulfur assimilation pathway
incorporating sulfide into amino acids in microorganisms and plants, however, these enzymes …

Background: Parkin, which when mutated leads to early-onset Parkinson’s disease, acts as
an E3 ubiquitin ligase. How Parkin is regulated for selective protein and organelle targeting …