Activator protein 1 (AP-1) (Fos/Jun) is a transcriptional regulator composed of members of
the Fos and Jun families of DNA binding proteins. The functions of AP-1 were initially studied …

The Jun proteins Jun, JunB and JunD are core members of activator protein-1 (AP-1), a
dimeric transcription factor complex consisting of homo- and heterodimers of the Jun, Fos, …

Psoriasis is a frequent, inflammatory disease of skin and joints with considerable morbidity.
Here we report that in psoriatic lesions, epidermal keratinocytes have decreased expression …

The transcription factor c-Jun mediates several cellular processes, including proliferation
and survival, and is upregulated in many carcinomas. Liver-specific inactivation of c-Jun at …

… mRNA and serum bile salt levels of the patients (r .77, r2 .54, P .… hepatic OATP2 mRNA
levels and serum bile salt levels (r … also inversely correlated with serum levels of total bilirubin (r …

To investigate the function of c-Jun during skin development and skin tumor formation, we
conditionally inactivated c-jun in the epidermis. Mice lacking c-jun in keratinocytes (c-jun Δep ) …

Mice lacking the AP-1 transcription factor c-Jun die around embryonic day E13.0 but little is
known about the cell types affected as well as the cause of embryonic lethality. Here we …

Background & Aims: Cholestasis is associated with retention of potentially toxic bile acids and
alterations in hepatocellular transporter expression. Conversely, nontoxic ursodeoxycholic …

Studies using genetically modified mice have revealed fundamental functions of the transcription
factor Fos/AP-1 in bone biology, inflammation, and cancer. However, the biological role …

Hepatocellular carcinoma (HCC) is a frequent cancer with limited treatment options and
poor prognosis. Tumorigenesis has been linked with macrophage-mediated chronic …