… MJ de Lange and RJ Nell contributed equally to this article. … RJ Nell is supported by the
European Union's Horizon 2020 research and innovation program under grant agreement no. …

Background Activating Gα q signalling mutations are considered an early event in the
development of uveal melanoma. Whereas most tumours harbour a mutation in GNAQ or GNA11, …

… restriction enzymes and digital PCR - Nell - 2020 - Human Mutation - Wiley Online Library
… Nell is supported by the European Union's Horizon 2020 research and innovation program …

Introduction Uveal melanoma is a lethal intraocular tumour, in which the presence of certain
genetic alterations correlates with the risk of metastatic dissemination and patient survival. …

Quantifying T cells accurately in a variety of tissues of benign, inflammatory, or malignant
origin can be of great importance in a variety of clinical applications. Flow cytometry and …

Uveal melanoma is an aggressive intraocular tumour characterised by a limited number of
genetic alterations. However, the evolution of this malignancy remains enigmatic. In this study…

Here, we discuss the presence and roles of heterogeneity in the development of uveal
melanoma. Both genetic and cellular heterogeneity are considered, as their presence became …

B cells fulfill an important role in the adaptive immunity. Upon activation and immunoglobulin
(IG) class switching, these cells function in the humoral immunity compartment as plasma …

T cells fulfill a central role in cell-mediated immunity and can be found in the circulation and
lymphoid organs upon maturation. For clinical applications, it can be important to quantify (…

The development of melanoma involves a sequence of genetic and epigenetic alterations.
CDKN2A is a key tumor suppressor gene that is commonly inactivated in invasive melanoma, …