The generation of neurons and glia in the developing nervous system is likely to be regulated
by extrinsic factors, including growth factors and neurotransmitters. Evidence from in vivo …

Human pluripotent stem cells (hPSCs) provide powerful resources for application in regenerative
medicine and pharmaceutical development. In the past decade, various methods have …

The culture of human embryonic stem cells (hESCs) is limited, both technically and with respect
to clinical potential, by the use of mouse embryonic fibroblasts (MEFs) as a feeder layer. …

… Nestin is clearly expressed in radial glial cells (Hockfield and McKay, 1985) as well as
proliferating neuronal stem cells (Frederiksen and McKay, 1988). These results are consistent …

The application of human embryonic stem (ES) cells in medicine and biology has an inherent
reliance on understanding the starting cell population. Human ES cells differ from mouse …

Knowing the rate of addition of new granule cells to the adult dentate gyrus is critical to
understanding the function of adult neurogenesis. Despite the large number of studies of …

Self-renewing, totipotent embryonic stem (ES) cells may provide a virtually unlimited donor
source for transplantation. A protocol that permits the in vitro generation of precursors for …

The hope of developing new transplantation therapies for degenerative diseases is limited
by inefficient stem cell growth and immunological incompatibility with the host 1 , 2 . Here we …

To understand the mechanism of the sequential restriction of multipotency of stem cells
during development, we have established culture conditions that allow the differentiation of …

The production of hippocampal granule neurons continues throughout adulthood but
dramatically decreases in old age. Here we show that reducing corticosteroid levels in aged rats …