BACKGROUND Elucidating the genetic architecture of neuropsychiatric disorders remains
a major scientific and medical challenge. Emerging genomic technologies now permit the …

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

Abnormalities of prefrontal cortical function are prominent features of schizophrenia and have
been associated with genetic risk, suggesting that susceptibility genes for schizophrenia …

… evidence for linkage has been reported in three chromosomal regions, each with some
degree of support in other data sets. In a study of 265 Irish pedigrees, Straub et al. (1995) …

A map of 191 single-nucleotide polymorphism (SNPs) was built across a 5-Mb segment
from chromosome 13q34 that has been genetically linked to schizophrenia. DNA from 213 …

Prior evidence has supported the existence of multiple susceptibility genes for schizophrenia.
Multipoint linkage analysis of the 270 Irish high-density pedigrees that we have studied, as …

Intelligence is highly heritable 1 and a major determinant of human health and well-being 2
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …

A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts
variation in human memory, and is associated with several neurological and psychiatric …

Disrupted-in-schizophrenia 1 (DISC1) is a promising schizophrenia candidate gene expressed
predominantly within the hippocampus. We typed 12 single-nucleotide polymorphisms (…

GRM3, a metabotropic glutamate receptor-modulating synaptic glutamate, is a promising
schizophrenia candidate gene. In a family-based association study, a common GRM3 …