Recently, substantial advances in the understanding of the molecular pathogenesis of
inflammatory bowel disease (IBD) have been made owing to three related lines of investigation. …

Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

Recent advances have provided substantial insight into the maintenance of mucosal immunity
and the pathogenesis of inflammatory bowel disease. Cellular programs responsible for …

Inflammatory bowel diseases (IBDs), including Crohn's disease (CD), are genetically linked
to host pathways that implicate an underlying role for aberrant immune responses to …

BACKGROUND Host immune responses are classically divided into innate immune responses,
which react rapidly and nonspecifically upon encountering a pathogen, and adaptive …

Background The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis
result from alterations in intestinal microbes and the immune system. However, the precise …

Studies of the roles of microbial communities in the development of inflammatory bowel
disease (IBD) have reached an important milestone. A decade of genome-wide association …

Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch
their core metabolism from oxidative phosphorylation to glycolysis 1 . Here we show that …

CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic
elements. To broadly enable the application of Cas9 in vivo, we established a Cre-…

Several risk factors for Crohn's disease have been identified in recent genome-wide association
studies. To advance gene discovery further, we combined data from three studies on …