Murine foetal liver supports limited detectable expansion of life-long haematopoietic progenitors
…, T Hall, J Myers, C Nevitt, R Sánchez-Lanzas… - Nature cell …, 2022 - nature.com
Current dogma asserts that the foetal liver (FL) is an expansion niche for recently specified
haematopoietic stem cells (HSCs) during ontogeny. Indeed, between embryonic day of …
haematopoietic stem cells (HSCs) during ontogeny. Indeed, between embryonic day of …
[HTML][HTML] Proteins directly interacting with mammalian 20S proteasomal subunits and ubiquitin-independent proteasomal degradation
R Sánchez-Lanzas, JG Castaño - Biomolecules, 2014 - mdpi.com
The mammalian 20S proteasome is a heterodimeric cylindrical complex (α7β7β7α7),
composed of four rings each composed of seven different α or β subunits with broad proteolytic …
composed of four rings each composed of seven different α or β subunits with broad proteolytic …
[HTML][HTML] Mitochondrial LonP1 protease is implicated in the degradation of unstable Parkinson's disease-associated DJ-1/PARK 7 missense mutants
R Sánchez-Lanzas, JG Castaño - Scientific Reports, 2021 - nature.com
DJ-1/PARK7 mutations are linked with familial forms of early-onset Parkinson's disease (PD).
We have studied the degradation of untagged DJ-1 wild type (WT) and missense mutants …
We have studied the degradation of untagged DJ-1 wild type (WT) and missense mutants …
Diversity in the bone marrow niche: classic and novel strategies to uncover niche composition
R Sánchez‐Lanzas, F Kalampalika… - British Journal of …, 2022 - Wiley Online Library
Our view on the role and composition of the bone marrow (BM) has dramatically changed
over time from a simple nutrient for the bone to a highly complex multicellular tissue that …
over time from a simple nutrient for the bone to a highly complex multicellular tissue that …
[HTML][HTML] CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease
…, S Alonso-Gil, R Sanchez-Lanzas… - Scientific Reports, 2017 - nature.com
The CCAAT/Enhancer binding protein β (C/EBPβ) is a transcription factor involved in
numerous physiological as well as pathological conditions in the brain. However, little is known …
numerous physiological as well as pathological conditions in the brain. However, little is known …
[HTML][HTML] Inhibitors of lysosomal function or serum starvation in control or LAMP2 deficient cells do not modify the cellular levels of Parkinson disease-associated DJ-1 …
R Sánchez-Lanzas, JG Castaño - Plos one, 2018 - journals.plos.org
Mutations in PARK7/DJ-1 gene are associated with familial autosomal recessive Parkinson
disease. Recently, lysosomes and chaperone mediated autophagy (CMA) has been …
disease. Recently, lysosomes and chaperone mediated autophagy (CMA) has been …
[HTML][HTML] Lysine-less variants of spinal muscular atrophy SMN and SMNΔ7 proteins are degraded by the proteasome pathway
R Sánchez-Lanzas, JG Castaño - International Journal of Molecular …, 2017 - mdpi.com
… Raúl Sánchez-Lanzas conducted the experimental work and data processing for figure
presentations, and participated in experimental design, discussion and writing of the manuscript. …
presentations, and participated in experimental design, discussion and writing of the manuscript. …
Vías de degradación de las proteínas α-sinucleína y DJ-1/PARK7 implicadas en la patogénesis de la enfermedad de Parkinson
R Sánchez Lanzas - 2019 - repositorio.uam.es
La degradación de proteínas juega un papel fundamental en la proteostasis celular siendo
uno de los factores más relevantes implicados en el desarrollo de las enfermedades …
uno de los factores más relevantes implicados en el desarrollo de las enfermedades …
Vías de degradación de las proteínas αlfa-sinucleína y dj-1/park7 implicadas en la patogénesis de la enfermedad de parkinson
RS Lanzas - 2019 - dialnet.unirioja.es
La degradación de proteínas juega un papel fundamental en la proteostasis celular siendo
uno de los factores más relevantes implicados en el desarrollo de las enfermedades …
uno de los factores más relevantes implicados en el desarrollo de las enfermedades …
[HTML][HTML] Protein degradation in a LAMP-2-deficient B-lymphoblastoid cell line from a patient with Danon disease
R Sánchez-Lanzas, B Alvarez-Castelao… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Danon disease, a condition characterized by cardiomyopathy, myopathy, and intellectual
disability, is caused by mutations in the LAMP-2 gene. Lamp-2A protein, generated by …
disability, is caused by mutations in the LAMP-2 gene. Lamp-2A protein, generated by …