User profiles for Rabeb Layouni

Rabeb Layouni

Research Scientist at Vertex Pharmaceuticals
Verified email at vanderbilt.edu
Cited by 86

Morlet wavelet filtering and phase analysis to reduce the limit of detection for thin film optical biosensors

SJ Ward, R Layouni, S Arshavsky-Graham, E Segal… - ACS …, 2021 - ACS Publications
The ultimate detection limit of optical biosensors is often limited by various noise sources,
including those introduced by the optical measurement setup. While sophisticated …

A smartphone biosensor based on analysing structural colour of porous silicon

T Cao, Y Zhao, CA Nattoo, R Layouni, SM Weiss - Analyst, 2019 - pubs.rsc.org
We report a smartphone compatible, low-cost porous silicon biosensor, which correlates the
structural colour of a porous silicon microcavity (PSiM) to spectral peak position. Molecules …

High contrast cleavage detection for enhancing porous silicon sensor sensitivity

R Layouni, M Dubrovsky, M Bao, H Chung, K Du… - Optics …, 2021 - opg.optica.org
Using porous silicon (PSi) interferometer sensors, we show the first experimental implementation
of the high contrast cleavage detection (HCCD) mechanism. HCCD makes use of …

Thermally carbonized porous silicon for robust label-free DNA optical sensing

R Layouni, MH Choudhury, PE Laibinis… - ACS Applied Bio …, 2019 - ACS Publications
In this work, thermal carbonization is shown to provide the necessary surface passivation to
enable highly robust DNA detection on a porous silicon (PSi) platform, overcoming previous …

Protein sensing using deep subwavelength-engineered photonic crystals

Y Zhang, CS Whittington, R Layouni, AM Cotto… - Optics Letters, 2024 - opg.optica.org
We demonstrate a higher sensitivity detection of proteins in a photonic crystal platform by
including a deep subwavelength feature in the unit cell that locally increases the energy …

[HTML][HTML] Peptide-Based Capture of Chikungunya Virus E2 Protein Using Porous Silicon Biosensor

R Layouni, T Cao, MB Coppock, PE Laibinis, SM Weiss - Sensors, 2021 - mdpi.com
The detection of pathogens presents specific challenges in ensuring that biosensors remain
operable despite exposure to elevated temperatures or other extreme conditions. The most …

Signal processing techniques to reduce the limit of detection for thin film biosensors

SJ Ward, R Layouni, S Arshavsky-Graham… - arXiv preprint arXiv …, 2021 - arxiv.org
The ultimate detection limit of optical biosensors is often limited by various noise sources,
including those introduced by the optical measurement setup. While sophisticated …

Use of peptide capture agents in porous silicon biosensors

T Cao, R Layouni, MB Coppock… - … to Systems XII, 2020 - spiedigitallibrary.org
We report the use of a peptide-based capture agent as an alternative to antibodies and
nucleic acid-based bioreceptors for porous silicon biosensors. Click chemistry is employed to …

Improved molecular detection sensitivity through photonic crystal unit cell design

Y Zhang, R Layouni, CS Whittington… - … to Systems XV, 2023 - spiedigitallibrary.org
We report improved surface sensing capabilities of photonic crystal biosensors through the
inclusion of a subwavelength dielectric feature inside the photonic crystal unit cell. …

Porous Silicon Optical Biosensor for Malaria

R Layouni, BA Baker, PE Laibinis… - 2022 IEEE Research …, 2022 - ieeexplore.ieee.org
We demonstrate detection of the malaria biomarker PfHRP2 using a porous silicon (PSi)
optical biosensor. Specificity was achieved with anti-PFHRP2 antibodies "clicked" to an azide-…