In bacteria, a fundamental level of gene regulation occurs by competitive association of
promoter-specificity factors called σs with RNA polymerase (RNAP). This σ cycle paradigm …

NusG is a conserved regulatory protein that interacts with elongation complexes (ECs) of RNA
polymerase, DNA, and RNA to modulate transcription in multiple and sometimes opposite …

NusG/RfaH/Spt5 transcription elongation factors are the only transcription regulators conserved
across all life. Bacterial NusG regulates RNA polymerase (RNAP) elongation complexes …

Sequence-specific pausing by RNA polymerase (RNAP) during transcription plays crucial and
diverse roles in gene expression. In bacteria, RNA structures are thought to fold within the …

10.7554/eLife.34823.001 Fidaxomicin (Fdx) is an antimicrobial RNA polymerase (RNAP)
inhibitor highly effective against Mycobacterium tuberculosis RNAP in vitro, but clinical use of …

The primary function of RNA polymerase (RNAP) is to produce RNA transcripts optimal for a
given environmental or developmental state of a cell. RNAP accomplishes this selection by …

10.7554/eLife.40981.001 Transcriptional pausing underlies regulation of cellular RNA
biogenesis. A consensus pause sequence that acts on RNA polymerases (RNAPs) from bacteria …

10.7554/eLife.21297.001 In bacteria, the regulation of gene expression by cis-acting
transcriptional riboswitches located in the 5'-untranslated regions of messenger RNA requires the …

Transcriptional riboswitches modulate downstream gene expression by a tight coupling of
ligand-dependent RNA folding kinetics with the rate of transcription. RNA folding pathways …

The conformational dynamics of the polymorphous trigger loop (TL) in RNA polymerase (RNAP)
underlie multiple steps in the nucleotide addition cycle and diverse regulatory …