Ovarian cancer and triple-negative breast cancer are among the most lethal diseases
affecting women, with few targeted therapies and high rates of metastasis. Cancer cells are …

Loss of skeletal integrity during ageing and disease is associated with an imbalance in the
opposing actions of osteoblasts and osteoclasts 1 . Here we show that intrinsic ageing of …

Stem cell regulation and hierarchical organization of human skeletal progenitors remain
largely unexplored. Here, we report the isolation of a self-renewing and multipotent human …

The disialoganglioside GD2 is overexpressed on several solid tumors, and monoclonal
antibodies targeting GD2 have substantially improved outcomes for children with high-risk …

Background: Considerable evidence suggests that the time of day at which calories are
consumed markedly impacts body weight gain and adiposity. However, a precise quantification …

Circadian clocks are cell autonomous, transcriptionally based, molecular mechanisms that
confer the selective advantage of anticipation, enabling cells/organs to respond to …

The cardiomyocyte circadian clock directly regulates multiple myocardial functions in a time-of-day-dependent
manner, including gene expression, metabolism, contractility, and …

Context: Chronic lower leg pain in athletes can be a frustrating problem for patients and a
difficult diagnosis for clinicians. Myriad approaches have been suggested to evaluate these …

There are limited methods available to study skeletal stem, progenitor, and progeny cell activity
in normal and diseased contexts. Most protocols for skeletal stem cell isolation are based …

Cardiovascular physiology exhibits time-of-day-dependent oscillations, which are mediated
by both extrinsic (eg, environment/behavior) and intrinsic (eg, circadian clock) factors. …