[HTML][HTML] CRISPR/Cas9 gene editing for the creation of an MGAT1-deficient CHO cell line to control HIV-1 vaccine glycosylation
…, SM O'Rourke, DL Alexander, B Yu, RC Doran… - PLoS …, 2018 - journals.plos.org
Over the last decade, multiple broadly neutralizing monoclonal antibodies (bN-mAbs) to the
HIV-1 envelope protein (Env) gp120 have been described. Many of these recognize …
HIV-1 envelope protein (Env) gp120 have been described. Many of these recognize …
[HTML][HTML] Glycan modifications to the gp120 immunogens used in the RV144 vaccine trial improve binding to broadly neutralizing antibodies
RC Doran, GP Tatsuno, SM O'Rourke, B Yu… - PloS one, 2018 - journals.plos.org
To date, the RV144 HIV vaccine trial has been the only study to show that immunization can
confer protection from HIV infection. While encouraging, the modest 31.2% (P = 0.04) …
confer protection from HIV infection. While encouraging, the modest 31.2% (P = 0.04) …
[HTML][HTML] Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production
…, G Tatsuno, M Wright, B Yu, KA Mesa, RC Doran… - PloS one, 2018 - journals.plos.org
The production of envelope glycoproteins (Envs) for use as HIV vaccines is challenging.
The yield of Envs expressed in stable Chinese Hamster Ovary (CHO) cell lines is typically 10–…
The yield of Envs expressed in stable Chinese Hamster Ovary (CHO) cell lines is typically 10–…
Characterization of a monoclonal antibody to a novel glycan-dependent epitope in the V1/V2 domain of the HIV-1 envelope protein, gp120
RC Doran, JF Morales, B To, TJ Morin, R Theolis Jr… - Molecular …, 2014 - Elsevier
Recent studies have described several broadly neutralizing monoclonal antibodies (bN-mAbs)
that recognize glycan-dependent epitopes (GDEs) in the HIV-1 envelope protein, gp120. …
that recognize glycan-dependent epitopes (GDEs) in the HIV-1 envelope protein, gp120. …
[HTML][HTML] Development of a Stable MGAT1− CHO Cell Line to Produce Clade C gp120 With Improved Binding to Broadly Neutralizing Antibodies
RC Doran, B Yu, M Wright, SM O'Rourke, L Yin… - Frontiers in …, 2018 - frontiersin.org
The high rate of new HIV infections, particularly in Sub-Saharan Africa, emphasizes the need
for a safe and effective vaccine to prevent acquired immunodeficiency syndrome (AIDS). To …
for a safe and effective vaccine to prevent acquired immunodeficiency syndrome (AIDS). To …
[HTML][HTML] Abstracts from the 5th International Conference for Healthcare and Medical Students (ICHAMS) Dublin, Ireland. 19-20 February 2016
Table of contents O1: Assessing the protective effect of dexrazoxane against doxorubicin-induced
toxicity in HL-1 cardiomyocytes Yvonne Sweeney, Hugh O’Neill, Garry Duffy O2: Role …
toxicity in HL-1 cardiomyocytes Yvonne Sweeney, Hugh O’Neill, Garry Duffy O2: Role …
Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double …
…, C Pan, J Keenan, J Milton, Z Doran, C Bray… - The lancet Diabetes & …, 2017 - thelancet.com
Background The effect of the α-glucosidase inhibitor acarbose on cardiovascular outcomes
in patients with coronary heart disease and impaired glucose tolerance is unknown. We …
in patients with coronary heart disease and impaired glucose tolerance is unknown. We …
[HTML][HTML] Effect of point-of-care C-reactive protein testing on antibiotic prescription in febrile patients attending primary care in Thailand and Myanmar: an open-label …
…, N Sumpradit, S Dittrich, Z Doran… - The Lancet Global …, 2019 - thelancet.com
Background In southeast Asia, antibiotic prescription in febrile patients attending primary care
is common, and a probable contributor to the high burden of antimicrobial resistance. The …
is common, and a probable contributor to the high burden of antimicrobial resistance. The …
Improvements to a GP120 Based Subunit Vaccine for HIV
R Doran - 2018 - escholarship.org
… Rachel C Doran … The work was completed as a collaboration between all authors, Rachel
C. Doran, Bin Yu, Meredith Wright, Sara M. O’Rourke, Lu Yin, Jennie M. Richardson, Gabriel …
C. Doran, Bin Yu, Meredith Wright, Sara M. O’Rourke, Lu Yin, Jennie M. Richardson, Gabriel …
[BOOK][B] Applications of geometric algebra in computer science and engineering
Geometric algebra has established itself as a powerful and valuable mathematical tool for
solving problems in computer science, engineering, physics, and mathematics. The articles in …
solving problems in computer science, engineering, physics, and mathematics. The articles in …