Transmembrane member 16A (TMEM16A) is a widely expressed Ca 2+ -activated Cl −
channel with various physiological functions ranging from mucosal secretion to regulating …

Toxoplasma gondii is a useful model for intracellular parasitism given its ease of culture in
the laboratory and genomic resources. However, as for many other eukaryotes, the T. gondii …

One of the earliest and most prevalent barriers to successful reproduction is polyspermy, or
fertilization of an egg by multiple sperm. To prevent these supernumerary fertilizations, eggs …

Following the fertilization of an egg by a single sperm, the egg coat or zona pellucida (ZP)
hardens and polyspermy is irreversibly blocked. These events are associated with the …

TransMEMbrane 16A (TMEM16A) is a Ca 2+ -activated Cl − channel that plays critical roles
in regulating diverse physiologic processes, including vascular tone, sensory signal …

Fertilization of an egg by more than one sperm, a condition known as polyspermy, leads to
gross chromosomal abnormalities and is embryonic lethal for most animals. Consequently, …

The Ca 2+ -conducting ion channel, CatSper, is expressed exclusively on the sperm flagellum
and regulates sperm motility. A new study (Hwang et al., Cell, 2019) reveals that the pH-…

Post-fertilization cleavage of glycoprotein ZP2, a major subunit of egg zona pellucida (ZP)
filaments, is crucial for mammalian reproduction by irreversibly blocking polyspermy. ZP2 …

Seminal fluid in humans contain approximately 1-3 mM zinc, more than 100-fold higher than
the amount circulating throughout the human body. Zinc is both essential and the most …

Fertilization of eggs from the African clawed frog Xenopus laevis is characterized by an
increase in cytosolic calcium, a phenomenon that is also observed in other vertebrates such as …