Long-term dietary intake influences the structure and activity of the trillions of microorganisms
residing in the human gut 1 , 2 , 3 , 4 , 5 , but it remains unclear how rapidly and …

Genomics and metabolomics are widely used to explore specialized metabolite diversity.
The Paired Omics Data Platform is a community initiative to systematically document links …

Tractable microbial communities are needed to bridge the gap between observations of
patterns of microbial diversity and mechanisms that can explain these patterns. We developed …

The potential of the diverse chemistries present in natural products (NP) for biotechnology
and medicine remains untapped because NP databases are not searchable with raw data …

Microbial communities of fermented foods have provided humans with tools for preservation
and flavor development for thousands of years. These simple, reproducible, accessible, …

Microbial interactions are expected to be major determinants of microbiome structure and
function. Although fungi are found in diverse microbiomes, their interactions with bacteria …

The vast majority of bacteria, including human pathogens and microbiome species, lack
genetic tools needed to systematically associate genes with phenotypes. This is the major …

Protein disulfide bond formation contributes to the folding and activity of many exported
proteins in bacteria. However, information about disulfide bond formation is limited to only a few …

Microorganisms such as bacteria and fungi produce a variety of specialized metabolites that
are invaluable for agriculture, biological research, and drug discovery. However, the …

Vitamin K epoxide reductase (VKOR) generates vitamin K hydroquinone to sustain γ-carboxylation
of many blood coagulation factors. Here, we report the 3.6 Å crystal structure of a …