Protein-restricted (PR), high-carbohydrate diets improve metabolic health in rodents, yet the
precise dietary components that are responsible for these effects have not been identified. …

Key points We recently found that feeding healthy mice a diet with reduced levels of
branched-chain amino acids (BCAAs), which are associated with insulin resistance in both humans …

There is growing concern over confounding artifacts associated with β-cell–specific Cre-recombinase
transgenic models, raising questions about their general usefulness in research. …

Prostaglandin E 2 (PGE 2 ) is derived from arachidonic acid, whereas PGE 3 is derived from
eicosapentaenoic acid (EPA) using the same downstream metabolic enzymes. Little is …

The noninvasive measurement of functional β-cell mass would be clinically valuable for
monitoring the progression of type 1 and type 2 diabetes as well as the viability of transplanted …

Over half of patients with type 2 diabetes (T2D) are unable to achieve blood glucose targets
despite therapeutic compliance, significantly increasing their risk of long-term complications. …

The transition from β-cell compensation to β-cell failure is not well understood. Previous
works by our group and others have demonstrated a role for Prostaglandin EP3 receptor (EP3), …

Type 2 diabetes (T2D) is a rising pandemic worldwide. Diet and lifestyle changes are typically
the first intervention for T2D. When this intervention fails, the biguanide metformin is the …

The α-subunit of the heterotrimeric G z protein, Gα z , promotes β-cell death and inhibits β-cell
replication when pancreatic islets are challenged by stressors. Thus, we hypothesized that …

Glut1 deficiency syndrome is caused by SLC2A1 mutations on chromosome 1p34.2 that
impairs glucose transport across the blood–brain barrier resulting in hypoglycorrhachia and …