Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50%
of phenotypic variation in human height, but identifying the specific variants and …

Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied
prevalence worldwide owing to different dietary patterns and medication use 1 . Despite …

We report a genome-wide association study (GWAS) of coronary artery disease (CAD)
incorporating nearly a quarter of a million cases, in which existing studies are integrated with data …

Behaviors and disorders related to self-regulation, such as substance use, antisocial behavior
and attention-deficit/hyperactivity disorder, are collectively referred to as externalizing and …

Problematic alcohol use (PAU) is a leading cause of death and disability worldwide. Although
genome-wide association studies have identified PAU risk genes, the genetic architecture …

Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately
heritable traits. We conduct genome-wide association studies of these traits using longitudinal …

Importance With the current opioid crisis, it is important to improve understanding of the
biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk variants …

Despite an estimated heritability of ~50%, genome-wide association studies of opioid use
disorder (OUD) have revealed few genome-wide significant loci. We conducted a cross-…

Despite the large toll of opioid use disorder (OUD), genome-wide association studies (GWAS)
of OUD to date have yielded few susceptibility loci. We performed a large-scale GWAS of …

Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using
a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels …