To broadly explore mitochondrial structure and function as well as the communication of
mitochondria with other cellular pathways, we constructed a quantitative, high-density genetic …

Two dynamin-related protein (DRP) families are essential for fusion of the outer and inner
mitochondrial membranes, Fzo1 (yeast)/Mfn1/Mfn2 (mammals) and Mgm1 (yeast)/Opa1 (…

Target-mediated clearance and high antigen load can hamper the efficacy and dosage of
many antibodies. We show for the first time that the mouse, cynomolgus, and human cross-…

Proprotein convertase subtilisin/kexin type 9 ( PCSK9 ) promotes atherosclerosis by increasing
low‐density lipoprotein ( LDL ) cholesterol levels through degradation of hepatic LDL …

Aims Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes the degradation of
hepatic low-density lipoprotein (LDL) receptors (LDLR), thereby, decreasing hepatocyte LDL-…

Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates low density lipoprotein
receptor protein levels by diverting it to lysosomes. Monoclonal antibody therapeutics aimed to …

Antibody drug conjugates (ADCs) provide an efficacious and relatively safe means by which
chemotherapeutic agents can be specifically targeted to cancer cells. In addition to the …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a soluble protein that directs
membrane-bound receptors to lysosomes for degradation. In the most studied example of this, …

OBJECTIVES: Disulfiram, a low-cost generic drug used for alcohol dependence, holds the
potential to mitigate disease progression in patients with moderate COVID-19 by targeting …

Age-related immune dysregulation contributes to increased susceptibility to infection and
disease in older adults. We combined high-throughput laboratory automation with machine …