User profiles for Rachel M. Wheatley
Rachel WheatleyQueen's University Belfast Verified email at qub.ac.uk Cited by 522 |
[HTML][HTML] Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient
Bacteria have the potential to translocate between sites in the human body, but the dynamics
and consequences of within-host bacterial migration remain poorly understood. Here we …
and consequences of within-host bacterial migration remain poorly understood. Here we …
Understanding the impacts of bacteriophage viruses: from laboratory evolution to natural ecosystems
…, CA Hernandez, RM Wheatley - Annual Review of …, 2022 - annualreviews.org
Viruses of bacteria (bacteriophages or phage) have broad effects on bacterial ecology and
evolution in nature that mediate microbial interactions, shape bacterial diversity, and …
evolution in nature that mediate microbial interactions, shape bacterial diversity, and …
Lifestyle adaptations of Rhizobium from rhizosphere to symbiosis
RM Wheatley, BL Ford, L Li… - Proceedings of the …, 2020 - National Acad Sciences
By analyzing successive lifestyle stages of a model Rhizobium–legume symbiosis using
mariner-based transposon insertion sequencing (INSeq), we have defined the genes required …
mariner-based transposon insertion sequencing (INSeq), we have defined the genes required …
Metabolic control of nitrogen fixation in rhizobium-legume symbioses
Rhizobia induce nodule formation on legume roots and differentiate into bacteroids, which
catabolize plant-derived dicarboxylates to reduce atmospheric N 2 into ammonia. Despite the …
catabolize plant-derived dicarboxylates to reduce atmospheric N 2 into ammonia. Despite the …
[HTML][HTML] Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients
J Diaz Caballero, RM Wheatley, N Kapel… - Nature …, 2023 - nature.com
Antibiotic resistance poses a global health threat, but the within-host drivers of resistance
remain poorly understood. Pathogen populations are often assumed to be clonal within hosts, …
remain poorly understood. Pathogen populations are often assumed to be clonal within hosts, …
CRISPR-Cas systems restrict horizontal gene transfer in Pseudomonas aeruginosa
RM Wheatley, RC MacLean - The ISME journal, 2021 - academic.oup.com
CRISPR-Cas systems provide bacteria and archaea with an adaptive immune system that
targets foreign DNA. However, the xenogenic nature of immunity provided by CRISPR-Cas …
targets foreign DNA. However, the xenogenic nature of immunity provided by CRISPR-Cas …
Mechanisms of bacterial attachment to roots
RM Wheatley, PS Poole - FEMS microbiology reviews, 2018 - academic.oup.com
The attachment of bacteria to roots constitutes the first physical step in many plant–microbe
interactions. These interactions exert both positive and negative influences on agricultural …
interactions. These interactions exert both positive and negative influences on agricultural …
Fitness costs of CRISPR-Cas systems in bacteria
M Zaayman, RM Wheatley - Microbiology, 2022 - microbiologyresearch.org
CRISPR-Cas systems provide bacteria with both specificity and adaptability in defence against
invading genetic elements. From a theoretical perspective, CRISPR-Cas systems confer …
invading genetic elements. From a theoretical perspective, CRISPR-Cas systems confer …
Role of O2 in the Growth of Rhizobium leguminosarum bv. viciae 3841 on Glucose and Succinate
RM Wheatley, VK Ramachandran… - Journal of …, 2017 - Am Soc Microbiol
Insertion sequencing (INSeq) analysis of Rhizobium leguminosarum bv. viciae 3841 (Rlv3841)
grown on glucose or succinate at both 21% and 1% O 2 was used to understand how O 2 …
grown on glucose or succinate at both 21% and 1% O 2 was used to understand how O 2 …
Interkingdom interactions between Pseudomonas aeruginosa and Candida albicans affect clinical outcomes and antimicrobial responses
Infections that involve interkingdom microbial communities, such as those between bacteria
and yeast pathogens, are difficult to treat, associated with worse patient outcomes, and may …
and yeast pathogens, are difficult to treat, associated with worse patient outcomes, and may …