User profiles for Rachel M. Wheatley

Rachel Wheatley

Queen's University Belfast
Verified email at qub.ac.uk
Cited by 522

[HTML][HTML] Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient

RM Wheatley, JD Caballero, TE van der Schalk… - Nature …, 2022 - nature.com
Bacteria have the potential to translocate between sites in the human body, but the dynamics
and consequences of within-host bacterial migration remain poorly understood. Here we …

Understanding the impacts of bacteriophage viruses: from laboratory evolution to natural ecosystems

…, CA Hernandez, RM Wheatley - Annual Review of …, 2022 - annualreviews.org
Viruses of bacteria (bacteriophages or phage) have broad effects on bacterial ecology and
evolution in nature that mediate microbial interactions, shape bacterial diversity, and …

Lifestyle adaptations of Rhizobium from rhizosphere to symbiosis

RM Wheatley, BL Ford, L Li… - Proceedings of the …, 2020 - National Acad Sciences
By analyzing successive lifestyle stages of a model Rhizobium–legume symbiosis using
mariner-based transposon insertion sequencing (INSeq), we have defined the genes required …

Metabolic control of nitrogen fixation in rhizobium-legume symbioses

CCM Schulte, K Borah, RM Wheatley, JJ Terpolilli… - Science …, 2021 - science.org
Rhizobia induce nodule formation on legume roots and differentiate into bacteroids, which
catabolize plant-derived dicarboxylates to reduce atmospheric N 2 into ammonia. Despite the …

[HTML][HTML] Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients

J Diaz Caballero, RM Wheatley, N Kapel… - Nature …, 2023 - nature.com
Antibiotic resistance poses a global health threat, but the within-host drivers of resistance
remain poorly understood. Pathogen populations are often assumed to be clonal within hosts, …

CRISPR-Cas systems restrict horizontal gene transfer in Pseudomonas aeruginosa

RM Wheatley, RC MacLean - The ISME journal, 2021 - academic.oup.com
CRISPR-Cas systems provide bacteria and archaea with an adaptive immune system that
targets foreign DNA. However, the xenogenic nature of immunity provided by CRISPR-Cas …

Mechanisms of bacterial attachment to roots

RM Wheatley, PS Poole - FEMS microbiology reviews, 2018 - academic.oup.com
The attachment of bacteria to roots constitutes the first physical step in many plant–microbe
interactions. These interactions exert both positive and negative influences on agricultural …

Fitness costs of CRISPR-Cas systems in bacteria

M Zaayman, RM Wheatley - Microbiology, 2022 - microbiologyresearch.org
CRISPR-Cas systems provide bacteria with both specificity and adaptability in defence against
invading genetic elements. From a theoretical perspective, CRISPR-Cas systems confer …

Role of O2 in the Growth of Rhizobium leguminosarum bv. viciae 3841 on Glucose and Succinate

RM Wheatley, VK Ramachandran… - Journal of …, 2017 - Am Soc Microbiol
Insertion sequencing (INSeq) analysis of Rhizobium leguminosarum bv. viciae 3841 (Rlv3841)
grown on glucose or succinate at both 21% and 1% O 2 was used to understand how O 2 …

Interkingdom interactions between Pseudomonas aeruginosa and Candida albicans affect clinical outcomes and antimicrobial responses

…, RM Wheatley, RC MacLean, M Ralser - Current Opinion in …, 2023 - Elsevier
Infections that involve interkingdom microbial communities, such as those between bacteria
and yeast pathogens, are difficult to treat, associated with worse patient outcomes, and may …