Background Multiple neuropsychiatric disorders, eg, depression, are linked to imbalances
in excitatory and inhibitory neurotransmission and prefrontal cortical dysfunction, and are …

Adolescence is a period of substantial neuroplasticity in stress regulatory neurocircuits.
Chronic stress exposure during this period leads to long-lasting changes in neuroendocrine …

The late adolescent period is characterized by marked neurodevelopmental and endocrine
fluctuations in the transition to early adulthood. Adolescents are highly responsive to the …

Hypofunction of the prefrontal cortex (PFC) contributes to stress-related neuropsychiatric
illnesses. Mechanisms leading to prefrontal hypoactivity remain to be determined. Prior …

Background The medial prefrontal cortex is necessary for appropriate appraisal of stressful
information, as well as coordinating visceral and behavioral processes. However, prolonged …

Clinical data suggest that the neuroendocrine stress response is chronically dysregulated in
a subset of patients with temporal lobe epilepsy (TLE), potentially contributing to both …

Exposure to prolonged stress is a major risk-factor for psychiatric disorders such as
generalized anxiety and major depressive disorder. Human imaging studies have identified …

10.7554/eLife.44672.001 Glucocorticoid receptors (GR) have diverse functions relevant to
maintenance of homeostasis and adaptation to environmental challenges. Understanding the …

Chronic stress drives behavioral and physiological changes associated with numerous
psychiatric disease states. In rodents, the vast majority of chronic stress models involve …

Chronic stress-associated pathologies frequently associate with alterations in the structure
and activity of the medial prefrontal cortex (mPFC). However, the influence of infralimbic …