Rheumatoid arthritis is a chronic disease that results in a disabling and painful condition as
it progresses to destruction of the articular cartilage and ankylosis of the joints. Although the …

Tryptophan as the precursor of several active compounds, including kynurenine and serotonin,
is critical for numerous important metabolic functions. Enhanced tryptophan metabolism …

Despite increasing evidence for a protective role of invariant (i) NKT cells in the control of
graft-versus-host disease (GVHD), the mechanisms underpinning regulation of the allogeneic …

Mastocytosis is a heterogeneous disease characterized by an abnormal accumulation of mast
cells (MCs) in 1 or several organs. Although a somatic KIT D816V mutation is detected in …

Monocytes are considered crucial actors of inflammation in sickle cell disease (SCD), being
responsible for an increased production of proinflammatory cytokines such as tumor …

Recent evidence has highlighted the role of histamine in inflammation. Since this monoamine
has also been strongly implicated in the pathogenesis of type-1 diabetes, we assessed its …

Background Gain-of-function variants of JAK1 drive a rare immune dysregulation syndrome
associated with atopic dermatitis, allergy, and eosinophilia. Objectives This study sought to …

Neuropilin-1 (NRP-1), the major co-receptor of vascular endothelial growth factor receptor-2
(VEGFR-2), may also independently act with VEGF-A 165 to stimulate tumour growth and …

Methods Study design We performed a prospective observational study between 2017 and
2019 in a pediatric French university hospital SCD reference center. Eligibility criteria were …

Invariant NKT (iNKT) cells differentiate in the thymus into three distinct lineages defined by
their cytokine and transcription factor expression. Signaling lymphocyte activation molecule (…