Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal
differentiation of the embryonic kidney. Here we show that overexpression of the …

Congenital anomalies of the kidneys and urinary tract (CAKUT) are the most common cause
of chronic kidney disease in the first three decades of life. Identification of single-gene …

There are considerable differences in tumour biology between adult and paediatric cancers.
The existence of cancer initiating cells/cancer stem cells (CIC/CSC) in paediatric solid …

Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause
of CKD in the first three decades of life. However, for most patients with CAKUT, the …

When assembling a nephron during development a multipotent stem cell pool becomes
restricted as differentiation ensues. A faulty differentiation arrest in this process leads to …

An open question remains in cancer stem cell (CSC) biology whether CSCs are by definition
at the top of the differentiation hierarchy of the tumor. Wilms' tumor (WT), composed of …

Background Systemic lupus erythematosus (SLE) comprise a diverse range of clinical
manifestations. To date, more than 30 single gene causes of lupus/lupus like syndromes in …

Cancer stem cell (CSC) identification relies on transplantation assays of cell subpopulations
sorted from fresh tumor samples. Here, we attempt to bypass limitations of abundant tumor …

Neutrophils are central players in the innate immune system. To protect against invading
pathogens, neutrophils can externalize chromatin to create neutrophil extracellular traps (NETs)…

Wilms’ tumor (WT), a common renal pediatric solid tumor, serves as a model for a malignancy
formed by renal precursor cells that have failed to differentiate properly. Here we review …