LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1
JM Lizcano, O Göransson, R Toth, M Deak… - The EMBO …, 2004 - embopress.org
We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the
pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP‐…
pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP‐…
Loss of iron triggers PINK1/Parkin‐independent mitophagy
In this study, we develop a simple assay to identify mitophagy inducers on the basis of the use
of fluorescently tagged mitochondria that undergo a colour change on lysosomal delivery. …
of fluorescently tagged mitochondria that undergo a colour change on lysosomal delivery. …
[HTML][HTML] Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair
…, GW Toh, L Sanchez-Pulido, JM Heuckmann, R Toth… - Molecular cell, 2009 - cell.com
Budding yeast Slx4 interacts with the structure-specific endonuclease Slx1 to ensure completion
of ribosomal DNA replication. Slx4 also interacts with the Rad1-Rad10 endonuclease to …
of ribosomal DNA replication. Slx4 also interacts with the Rad1-Rad10 endonuclease to …
Bioinformatic and experimental survey of 14-3-3-binding sites
…, MJ Stafford, DG Campbell, R Toth… - Biochemical …, 2010 - portlandpress.com
More than 200 phosphorylated 14-3-3-binding sites in the literature were analysed to define
14-3-3 specificities, identify relevant protein kinases, and give insights into how cellular 14-3…
14-3-3 specificities, identify relevant protein kinases, and give insights into how cellular 14-3…
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
…, J McIlrath, JM Park, A Wingate, CE Monk, R Toth… - Nature …, 2008 - nature.com
The kinases MSK1 and MSK2 are activated 'downstream' of the p38 and Erk1/2 mitogen-activated
protein kinases. Here we found that MSK1 and MSK2 were needed to limit the …
protein kinases. Here we found that MSK1 and MSK2 were needed to limit the …
[HTML][HTML] A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research
…, A Taggart, EC Thomson, L Tong, LS Torrie, R Toth… - PLoS …, 2021 - journals.plos.org
The recent emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2),
the underlying cause of Coronavirus Disease 2019 (COVID-19), has led to a worldwide …
the underlying cause of Coronavirus Disease 2019 (COVID-19), has led to a worldwide …
[HTML][HTML] PGE2 induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A–SIK–CRTC3 pathway
…, PGA Pedrioli, GJ Barton, R Toth… - The Journal of …, 2013 - journals.aai.org
The polarization of macrophages into a regulatory-like phenotype and the production of IL-10
plays an important role in the resolution of inflammation. We show in this study that PGE 2, …
plays an important role in the resolution of inflammation. We show in this study that PGE 2, …
Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators
S Chen, J Murphy, R Toth, DG Campbell… - Biochemical …, 2008 - portlandpress.com
AS160 (Akt substrate of 160 kDa) and TBC1D1 are related RabGAPs (Rab GTPase-activating
proteins) implicated in regulating the trafficking of GLUT4 (glucose transporter 4) storage …
proteins) implicated in regulating the trafficking of GLUT4 (glucose transporter 4) storage …
Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR
…, S Chen, JE Harthill, AF Ibrahim, R Toth… - Biochemical …, 2007 - portlandpress.com
AS160 (Akt substrate of 160 kDa) mediates insulin-stimulated GLUT4 (glucose transporter 4)
translocation, but is widely expressed in insulin-insensitive tissues lacking GLUT4. Having …
translocation, but is widely expressed in insulin-insensitive tissues lacking GLUT4. Having …
14-3-3-Pred: improved methods to predict 14-3-3-binding phosphopeptides
…, G Murugesan, E Berrett, M Stafford, R Toth… - …, 2015 - academic.oup.com
Motivation: The 14-3-3 family of phosphoprotein-binding proteins regulates many cellular
processes by docking onto pairs of phosphorylated Ser and Thr residues in a constellation of …
processes by docking onto pairs of phosphorylated Ser and Thr residues in a constellation of …