User profiles for Radha Desai

Radha Desai

MSD
Verified email at msd.com
Cited by 843

ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism

R Desai, AE Frazier, R Durigon, H Patel, AW Jones… - Brain, 2017 - academic.oup.com
Although mitochondrial disorders are clinically heterogeneous, they frequently involve the
central nervous system and are among the most common neurogenetic disorders. Identifying …

[PDF][PDF] Transglutaminase type 2 regulates ER-mitochondria contact sites by interacting with GRP75

…, L Occhigrossi, MG Farrace, D Faccenda, R Desai… - Cell reports, 2018 - cell.com
Transglutaminase type 2 (TG2) is a multifunctional enzyme that plays a key role in mitochondria
homeostasis under stressful cellular conditions. TG2 interactome analysis reveals an …

Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response

R Desai, DA East, L Hardy, D Faccenda, M Rigon… - Science …, 2020 - science.org
Mitochondria drive cellular adaptation to stress by retro-communicating with the nucleus.
This process is known as mitochondrial retrograde response (MRR) and is induced by …

Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria

G Akman, R Desai, LJ Bailey… - Proceedings of the …, 2016 - National Acad Sciences
The genetic information in mammalian mitochondrial DNA is densely packed; there are no
introns and only one sizeable noncoding, or control, region containing key cis-elements for its …

Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model

…, R Young, AWE Jones, K Reddy, R Desai… - Nucleic acids …, 2017 - academic.oup.com
All DNA polymerases misincorporate ribonucleotides despite their preference for
deoxyribonucleotides, and analysis of cultured cells indicates that mammalian mitochondrial DNA (…

Serotonin in pre-implantation mouse embryos is localized to the mitochondria and can modulate mitochondrial potential

B Basu, R Desai, J Balaji, R Chaerkady… - …, 2008 - rep.bioscientifica.com
Serotonin is reported to be present in early embryos of many species and plays an
important role in early patterning. Since it is a fluorophore, it can be directly visualized using …

Known drug space as a metric in exploring the boundaries of drug-like chemical space

A Mirza, R Desai, J Reynisson - European journal of medicinal chemistry, 2009 - Elsevier
In this work, marketed drug compounds (or known drug space) were used as a metric to test
the principles of eliminating parent structures of the nitrenium ion (aryl-amine/nitro …

Green approaches to field nitrate analysis: an electroanalytical perspective

R Desai, M Marti Villalba… - … Journal Devoted to …, 2009 - Wiley Online Library
The different approaches that have been taken in the development of analytical methods for
the determination of nitrate within the field are reviewed. The emphasis has been placed on …

Exploring mitochondrial cholesterol signalling for therapeutic intervention in neurological conditions

R Desai, M Campanella - British Journal of Pharmacology, 2019 - Wiley Online Library
The pharmacological targeting of cholesterol levels continues to generate interest due to the
undoubted success of therapeutic agents, such as statins, in extending life expectancy by …

[PDF][PDF] MitoCPR: Meticulous monitoring of mitochondrial proteostasis

R Desai, M Campanella - Molecular cell, 2018 - cell.com
Mitochondrial protein import stress compromises functioning of the organelles, due to
inadequate supply of inner mitochondrial proteins. Weidberg and Amon (2018) describe a new …