Preexisting commensal dysbiosis is a host-intrinsic regulator of tissue inflammation and tumor cell dissemination in hormone receptor–positive breast cancer

C Buchta Rosean, RR Bostic, JCM Ferey, TY Feng… - Cancer research, 2019 - AACR
Identification of commensal dysbiosis as a host-intrinsic factor mediating evolution of metastatic
breast cancer allows for development of interventions or diagnostic tools for patients at …

[HTML][HTML] Immunoglobulin superfamily receptor Junctional adhesion molecule 3 (Jam3) requirement for melanophore survival and patterning during formation of …

DS Eom, LB Patterson, RR Bostic, DM Parichy - Developmental biology, 2021 - Elsevier
Adhesive interactions are essential for tissue patterning and morphogenesis yet difficult to
study owing to functional redundancies across genes and gene families. A useful system in …

[HTML][HTML] Platinum chemotherapy induces lymphangiogenesis in cancerous and healthy tissues that can be prevented with adjuvant anti-VEGFR3 therapy

…, S Tkachenko, MJ Perez, CB Rosean, RR Bostic… - Frontiers in …, 2022 - frontiersin.org
Chemotherapy has been used to inhibit cancer growth for decades, but emerging evidence
shows it can affect the tumor stroma unintentionally promoting cancer malignancy. After …

[PDF][PDF] Starting conversations toward inclusion

F Karanja, RR Bostic, D DaCrema, GG Pacheco - Cell, 2020 - cell.com
Communal discussions on anti-racism and inclusion are crucial to addressing the history of
racism in scientific communities. Unfortunately, universities are not universally implementing …

Platinum chemotherapy induces lymphangiogenesis to prime tissues for tumor metastasis

…, S Esparza, MJ Perez, CB Rosean, RR Bostic… - bioRxiv, 2019 - biorxiv.org
Chemotherapy has been used to inhibit cancer growth for decades, but emerging evidence
shows it can affect the tumor stroma unintentionally promoting cancer malignancy. After …

Commensal dysbiosis alters the tumor microenvironment in luminal breast cancer

CM Buchta, RR Bostic, JE Kearney… - The Journal of …, 2017 - journals.aai.org
Many factors, including diet, race, and recurrent use of antibiotics, have been associated with
an adverse outcome in breast cancer. These extrinsic factors also significantly impact the …

Abstract A64: Commensal dysbiosis alters the tumor microenvironment in breast cancer and diminishes efficacy of PD-L1 blockade

CB Rosean, R Bostic, TY Feng, MR Rutkowski - Cancer Immunology …, 2020 - AACR
Hormone receptor-positive (HR+) breast cancer is largely nonresponsive to checkpoint
blockade therapy. Alterations in the composition of commensal microbes influence the systemic …

Commensal dysbiosis modulates the tumor microenvironment in breast cancer and diminishes efficacy of PD-L1 inhibition

MR Rutkowski, CM Rosean, R Bostic… - The Journal of …, 2018 - journals.aai.org
For patients with HR+ breast cancer, non-responsiveness to PD-1/PD-L1 blockade cannot
be attributed to poor immunogenicity, as immune-stimulatory gene signatures are associated …

[PDF][PDF] … of tissue inflammation and tumor cell dissemination in hormone receptor-positive breast cancer Claire Buchta Rosean1, Raegan R. Bostic2, Joshua CM Ferey3 …

FN Azar, KS Tung, MG Dozmorov, E Smirnova, PD Bos… - academia.edu
It is unknown why some patients with hormone receptor-positive (HR+) breast cancer
present with more aggressive and invasive disease. Metastatic dissemination occurs early in …

Two global crises bring opportunity to international tobacco control

CA Bostic - Sustainable Dev. L. & Pol'y, 2008 - HeinOnline
Tobacco can be grown in a variety of climates and soil types, and is grown in over 100
countries. 27 For most nations, it is a minor crop, accounting for less than one percent of total …