Culture of cells using various microfluidic devices is becoming more common within
experimental cell biology. At the same time, a technological radiation of microfluidic cell culture …

Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables
adaptability, limits therapeutic success, and remains incompletely understood. Single-cell RNA …

There is increasing demand for automated and quantitative cell culture technology, driven
both by the intense activity in stem cell biology and by the emergence of systems biology. We …

Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era.
We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data …

Time-dependent analysis of dynamic processes in single live cells is a revolutionary
technique for the quantitative studies of signaling networks. Here we describe an experimental …

The promise of single-objective light-sheet microscopy is to combine the convenience of
standard single-objective microscopes with the speed, coverage, resolution and gentleness of …

Poly(dimethyl siloxane) (PDMS)-based microfluidic devices are now commonly used for a
wide variety of biological experiments, including cell culture assays. However, the porous, …

Elucidating the developmental processes of organisms requires a comprehensive understanding
of cellular lineages in the spatial, temporal, and molecular domains. In this study, we …

Microfluidic technologies have been used across diverse disciplines (eg high-throughput
biological measurement, fluid physics, laboratory fluid manipulation) but widespread adoption …

High-throughput multiplexed proteomics of small-volume biospecimens will generate new
opportunities in theranostics. Achieving parallel top-down and bottom-up mass spectrometry …