How polycomb group proteins repress gene expression in vivo is not known. While histone-modifying
activities of the polycomb repressive complexes (PRCs) have been studied …

Histone methylation plays a key role in establishing and maintaining stable gene expression
patterns during cellular differentiation and embryonic development. Here, we report the …

Enhancer–promoter regulation is a fundamental mechanism underlying differential
transcriptional regulation. Spatial chromatin organization brings remote enhancers in contact with …

Two distinct Polycomb complexes, PRC1 and PRC2, collaborate to maintain epigenetic
repression of key developmental loci in embryonic stem cells (ESCs). PRC1 and PRC2 have …

A large portion of the eukaryotic genome is packaged into transcriptionally silent heterochromatin.
Several factors that play important roles during the establishment and maintenance of …

Although important for gene regulation, most studies of genome organization use either
fluorescence in situ hybridization (FISH) or chromosome conformation capture (3C) methods. …

Compared with histone H3, acetylation of H4 tails has not been well studied, especially in
mammalian cells. Yet, H4K16 acetylation is of particular interest because of its ability to …

The nuclear lamina is implicated in the organization of the eukaryotic nucleus. Association
of nuclear lamins with the genome occurs through large chromatin domains including mostly, …

Breast cancers exhibit genome-wide aberrant DNA methylation patterns. To investigate how
these affect the transcriptome and which changes are linked to transformation or …

The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription.
These proteins contain two related domains known as the chromo- and the chromoshadow-…