User profiles for Rahul S. Kathayat
 | Rahul Singh KathayatSt. Jude Children's Research Hospital Verified email at stjude.org Cited by 1144 |
[HTML][HTML] Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors
The pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
continues to expand. Papain-like protease (PLpro) is one of two SARS-CoV-2 proteases …
continues to expand. Papain-like protease (PLpro) is one of two SARS-CoV-2 proteases …
Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2
…, V Nicolaescu, S Dvorkin, K Furlong, RS Kathayat… - Science, 2021 - science.org
There is an urgent need for antiviral agents that treat severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection. We screened a library of 1900 clinically safe drugs …
coronavirus 2 (SARS-CoV-2) infection. We screened a library of 1900 clinically safe drugs …
[PDF][PDF] Palmitoylation couples insulin hypersecretion with β cell failure in diabetes
…, Z Shyr, S Morikawa, RA Kitamura, RS Kathayat… - Cell metabolism, 2023 - cell.com
Hyperinsulinemia often precedes type 2 diabetes. Palmitoylation, implicated in exocytosis,
is reversed by acyl-protein thioesterase 1 (APT1). APT1 biology was altered in pancreatic …
is reversed by acyl-protein thioesterase 1 (APT1). APT1 biology was altered in pancreatic …
ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5
S-Palmitoylation is a reversible lipid post-translational modification that has been observed
on mitochondrial proteins, but both the regulation and functional consequences of …
on mitochondrial proteins, but both the regulation and functional consequences of …
[HTML][HTML] Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes
RS Kathayat, Y Cao, PD Elvira, PA Sandoz… - Nature …, 2018 - nature.com
The reversible modification of cysteine residues by thioester formation with palmitate (S-palmitoylation)
is an abundant lipid post-translational modification (PTM) in mammalian systems. …
is an abundant lipid post-translational modification (PTM) in mammalian systems. …
A fluorescent probe for cysteine depalmitoylation reveals dynamic APT signaling
RS Kathayat, PD Elvira, BC Dickinson - Nature chemical biology, 2017 - nature.com
Hundreds of human proteins are modified by reversible palmitoylation of cysteine residues (S-palmitoylation),
but the regulation of depalmitoylation is poorly understood. Here, we …
but the regulation of depalmitoylation is poorly understood. Here, we …
Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration
…, H Klemp, C Bellotti, A Stäuble, T Qiu, RS Kathayat… - Science …, 2022 - science.org
Genetic CLN5 variants are associated with childhood neurodegeneration and Alzheimer’s
disease; however, the molecular function of ceroid lipofuscinosis neuronal protein 5 (Cln5) is …
disease; however, the molecular function of ceroid lipofuscinosis neuronal protein 5 (Cln5) is …
Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro
…, V Nicolaescu, S Dvorkin, K Furlong, RS Kathayat… - BioRxiv, 2020 - biorxiv.org
There is an urgent need for anti-viral agents that treat SARS-CoV-2 infection. The shortest
path to clinical use is repurposing of drugs that have an established safety profile in humans. …
path to clinical use is repurposing of drugs that have an established safety profile in humans. …
Bisindolylmaleimide IX: A novel anti-SARS-CoV2 agent targeting viral main protease 3CLpro demonstrated by virtual screening pipeline and in-vitro validation assays
SARS-CoV-2, the virus that causes COVID-19 consists of several enzymes with essential
functions within its proteome. Here, we focused on repurposing approved and investigational …
functions within its proteome. Here, we focused on repurposing approved and investigational …
[HTML][HTML] Palmitoylation is required for TNF-R1 signaling
…, T Glatter, L Caning, C Saggau, RS Kathayat… - Cell Communication and …, 2019 - Springer
Background Binding of tumor necrosis factor (TNF) to TNF-receptor 1 (TNF-R1) can induce
either cell survival or cell death. The selection between these diametrically opposed effects …
either cell survival or cell death. The selection between these diametrically opposed effects …