[HTML][HTML] Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease
R Zenz, R Eferl, C Scheinecker, K Redlich… - Arthritis research & …, 2008 - Springer
Activator protein 1 (AP-1) (Fos/Jun) is a transcriptional regulator composed of members of
the Fos and Jun families of DNA binding proteins. The functions of AP-1 were initially studied …
the Fos and Jun families of DNA binding proteins. The functions of AP-1 were initially studied …
Jun signalling in the epidermis: From developmental defects to psoriasis and skin tumors
R Zenz, EF Wagner - The international journal of biochemistry & cell biology, 2006 - Elsevier
The Jun proteins Jun, JunB and JunD are core members of activator protein-1 (AP-1), a
dimeric transcription factor complex consisting of homo- and heterodimers of the Jun, Fos, …
dimeric transcription factor complex consisting of homo- and heterodimers of the Jun, Fos, …
Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins
R Zenz, R Eferl, L Kenner, L Florin, L Hummerich… - Nature, 2005 - nature.com
Psoriasis is a frequent, inflammatory disease of skin and joints with considerable morbidity.
Here we report that in psoriatic lesions, epidermal keratinocytes have decreased expression …
Here we report that in psoriatic lesions, epidermal keratinocytes have decreased expression …
[HTML][HTML] Liver tumor development: c-Jun antagonizes the proapoptotic activity of p53
The transcription factor c-Jun mediates several cellular processes, including proliferation
and survival, and is upregulated in many carcinomas. Liver-specific inactivation of c-Jun at …
and survival, and is upregulated in many carcinomas. Liver-specific inactivation of c-Jun at …
Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases
G Zollner, P Fickert, R Zenz, A Fuchsbichler… - Hepatology, 2001 - Elsevier
Reduced hepatobiliary transporter expression could explain impaired hepatic uptake and
excretion of bile salts and other biliary constituents resulting in cholestasis and jaundice. …
excretion of bile salts and other biliary constituents resulting in cholestasis and jaundice. …
[PDF][PDF] c-Jun regulates eyelid closure and skin tumor development through EGFR signaling
R Zenz, H Scheuch, P Martin, C Frank, R Eferl… - Developmental cell, 2003 - cell.com
To investigate the function of c-Jun during skin development and skin tumor formation, we
conditionally inactivated c-jun in the epidermis. Mice lacking c-jun in keratinocytes (c-jun Δep ) …
conditionally inactivated c-jun in the epidermis. Mice lacking c-jun in keratinocytes (c-jun Δep ) …
Functions of c-Jun in liver and heart development
…, A Fuchsbichler, I Kufferath, B Guertl, R Zenz… - The Journal of cell …, 1999 - rupress.org
Mice lacking the AP-1 transcription factor c-Jun die around embryonic day E13.0 but little is
known about the cell types affected as well as the cause of embryonic lethality. Here we …
known about the cell types affected as well as the cause of embryonic lethality. Here we …
Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver
…, A Fuchsbichler, C Stumptner, C Pojer, R Zenz… - Gastroenterology, 2001 - Elsevier
Background & Aims: Cholestasis is associated with retention of potentially toxic bile acids and
alterations in hepatocellular transporter expression. Conversely, nontoxic ursodeoxycholic …
alterations in hepatocellular transporter expression. Conversely, nontoxic ursodeoxycholic …
EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation
Hepatocellular carcinoma (HCC) is a frequent cancer with limited treatment options and
poor prognosis. Tumorigenesis has been linked with macrophage-mediated chronic …
poor prognosis. Tumorigenesis has been linked with macrophage-mediated chronic …
Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1
…, M Rath, H Popper, R Zenz… - Proceedings of the …, 2008 - National Acad Sciences
Studies using genetically modified mice have revealed fundamental functions of the transcription
factor Fos/AP-1 in bone biology, inflammation, and cancer. However, the biological role …
factor Fos/AP-1 in bone biology, inflammation, and cancer. However, the biological role …