Background Dengue, a mosquito-borne viral disease, poses a significant global public health
risk. In tropical countries such as India where periodic dengue outbreaks can be correlated …

In the present study, resveratrol, a polyphenolic SIRT1 activator was evaluated for its SIRT1
activation in an in vitro fluorescent based assay (EC 50 : 7 μM). The efficacy of resveratrol …

The IRAK-4 kinase lies at a critical signaling node that drives cancer cell survival through
multiple mechanisms, activation, and translocation of NF-κB mediated inflammatory responses …

Background: Intracellular cyclic adenosine monophosphate (cAMP) in inflammatory cells
and airway smooth muscle is critical to the modulation of inflammatory response generation. …

The p38 mitogen activated protein kinase (MAPK) is a key signaling molecule that plays a
crucial role in the progression of various inflammatory diseases such as rheumatoid arthritis (…

Ceramide 1-phosphate (C1P) possesses emerging and diversified roles in the regulation of
various physiological and pathological processes, including cell proliferation, apoptosis and …

The purpose of the article To identify novel small molecule antagonists of Urotensin II
receptor with acceptable pharmacological profile. Materials and methods Structure-activity-…

Formyl peptide receptor (FPR) family members have been reported to play important role in
the resolution of inflammation. A few FPR2/FPR1 dual agonists are reported in the public …

Introduction: Therapies that abrogate eosinophilic airway inflammation are beneficial in
treatment of asthma. PI3K delta, a class IA PI3 kinase is integral in the orchestration of both …

Shodhganga@INFLIBNET: Evaluation of Topical Formulations of Selective Cyclooxygenase 2
COX 2 Inhibitors for Analgesic and Anti inflammatory Efficacy as well as Plasma Concentration …