User profiles for Rajewsky Nikolaus

Nikolaus Rajewsky

Professor, Systems Biology, Max Delbruck Center for Molecular Medicine, Berlin
Verified email at mdc-berlin.de
Cited by 72520

The evolution of gene regulation by transcription factors and microRNAs

K Chen, N Rajewsky - Nature Reviews Genetics, 2007 - nature.com
Abstract Changes in the patterns of gene expression are widely believed to underlie many
of the phenotypic differences within and between species. Although much emphasis has …

microRNA target predictions in animals

N Rajewsky - Nature genetics, 2006 - nature.com
In recent years, microRNAs (miRNAs) have emerged as a major class of regulatory genes,
present in most metazoans and important for a diverse range of biological functions. Because …

Best practice standards for circular RNA research

…, RJ Pasterkamp, S Preibisch, N Rajewsky… - Nature …, 2022 - nature.com
Circular RNAs (circRNAs) are formed in all domains of life and via different mechanisms.
There has been an explosion in the number of circRNA papers in recent years; however, as a …

Circular RNAs are a large class of animal RNAs with regulatory potency

…, M Landthaler, C Kocks, F Le Noble, N Rajewsky - Nature, 2013 - nature.com
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function.
To explore circRNAs systematically, we sequenced and computationally analysed human, …

Combinatorial microRNA target predictions

…, I Da Piedade, KC Gunsalus, M Stoffel, N Rajewsky - Nature …, 2005 - nature.com
MicroRNAs are small noncoding RNAs that recognize and bind to partially complementary
sites in the 3′ untranslated regions of target genes in animals and, by unknown mechanisms…

Silencing of microRNAs in vivo with 'antagomirs'

J Krützfeldt, N Rajewsky, R Braich, KG Rajeev… - nature, 2005 - nature.com
MicroRNAs (miRNAs) are an abundant class of non-coding RNAs that are believed to be
important in many biological processes through regulation of gene expression 1 , 2 , 3 . The …

Widespread changes in protein synthesis induced by microRNAs

…, N Thierfelder, Z Fang, R Khanin, N Rajewsky - nature, 2008 - nature.com
Animal microRNAs (miRNAs) regulate gene expression by inhibiting translation and/or by
inducing degradation of target messenger RNAs. It is unknown how much translational control …

miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades

…, SD Mackowiak, N Li, W Chen, N Rajewsky - Nucleic acids …, 2012 - academic.oup.com
microRNAs (miRNAs) are a large class of small non-coding RNAs which post-transcriptionally
regulate the expression of a large fraction of all animal genes and are important in a wide …

[PDF][PDF] circRNA biogenesis competes with pre-mRNA splicing

…, M Hanan, N Evantal, S Memczak, N Rajewsky… - Molecular cell, 2014 - cell.com
Circular RNAs (circRNAs) are widely expressed noncoding RNAs. However, their biogenesis
and possible functions are poorly understood. Here, by studying circRNAs that we …

A pancreatic islet-specific microRNA regulates insulin secretion

…, X Ma, PE Macdonald, S Pfeffer, T Tuschl, N Rajewsky… - Nature, 2004 - nature.com
MicroRNAs (miRNAs) constitute a growing class of non-coding RNAs that are thought to
regulate gene expression by translational repression 1 . Several miRNAs in animals exhibit …