We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs, and
disease states are connected by virtue of common gene-expression signatures. Here, we …

CORRESPONDENCE (tool compounds are valuable for achieving the target redundancy
needed to differentiate on-target from off-target activities of clinical drugs being considered for …

Anticancer uses of non-oncology drugs have occasionally been found, but such discoveries
have been serendipitous. We sought to create a public resource containing the growth-…

Malignant melanomas harbouring point mutations (Val600Glu) in the serine/threonine-protein
kinase BRAF (BRAF(V600E)) depend on RAF–MEK–ERK signalling for tumour cell …

Motivation: Large-scale gene expression profiling has been widely used to characterize cellular
states in response to various disease conditions, genetic perturbations, etc. Although the …

Introduction Ribosome biogenesis is commonly up-regulated to satisfy the increased anabolic
demands associated with malignant transformation and tumor growth. Many different …

Many bioinformatics methods have been proposed for reducing the complexity of large gene
or protein networks into relevant subnetworks or modules. Yet, how such methods compare …

Recent genome sequencing efforts have identified millions of somatic mutations in cancer.
However, the functional impact of most variants is poorly understood. Here we characterize …

The application of RNA interference (RNAi) to mammalian cells has provided the means to
perform phenotypic screens to determine the functions of genes. Although RNAi has …

High-throughput screening has become a mainstay of small-molecule probe and early drug
discovery. The question of how to build and evolve efficient screening collections …