Intrinsic malignant brain tumors, such as glioblastomas are frequently resistant to immune
checkpoint blockade (ICB) with few hypermutated glioblastomas showing response. Modeling …

Defects in long-range regulatory elements have recently emerged as previously underestimated
factors in the genesis of human congenital disorders. Léri-Weill dyschondrosteosis is a …

The interaction between the mammalian host and its resident gut microbiota is known to license
adaptive immune responses. Nutritional constituents strongly influence composition and …

Background There is increasing evidence that Parkinson’s disease (PD) might start in the
gut, thus involving and compromising also the enteric nervous system (ENS). At the clinical …

Irritable bowel syndrome (IBS) is a gut-brain disorder involving alterations in intestinal
sensitivity and motility. Serotonin 5-HT 4 receptors are promising candidates in IBS …

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia with a strong genetic component.
Molecular pathways involving the homeodomain transcription factor Shox2 control the …

Background: Head and neck squamous cell carcinomas (HNSCC) lack tumor-specific
biomarkers. Exosomes from HNSCC patients carry immunomodulatory molecules, and correlate …

Haploinsufficiency of the short stature homeobox gene SHOX has been found in patients
with idiopathic short stature (ISS) and Leri‐Weill dyschondrosteosis (LWD). In addition to …

Clinical studies in glioblastoma and pancreatic carcinoma patients strongly support the
further development of H-1 protoparvovirus (H-1PV)-based anticancer therapies. The …

Mutations in SHANK genes play an undisputed role in neuropsychiatric disorders. Until now,
research has focused on the postsynaptic function of SHANKs, and prominent postsynaptic …