Fibroblast growth factor signaling during early vertebrate development

RT Bottcher, C Niehrs - Endocrine reviews, 2005 - academic.oup.com
Fibroblast growth factors (FGFs) have been implicated in diverse cellular processes
including apoptosis, cell survival, chemotaxis, cell adhesion, migration, differentiation, and …

Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail

RT Böttcher, C Stremmel, A Meves, H Meyer… - Nature cell …, 2012 - nature.com
Integrin functions are controlled by regulating their affinity for ligand, and by the efficient
recycling of intact integrins through endosomes. Here we demonstrate that the Kindlin-binding …

[PDF][PDF] Migrating platelets are mechano-scavengers that collect and bundle bacteria

…, S Helmer, B Striednig, K Stark, M Janko, RT Böttcher… - Cell, 2017 - cell.com
Blood platelets are critical for hemostasis and thrombosis and play diverse roles during immune
responses. Despite these versatile tasks in mammalian biology, their skills on a cellular …

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

M Theodosiou, M Widmaier, RT Böttcher, E Rognoni… - Elife, 2016 - elifesciences.org
10.7554/eLife.10130.001 Integrins require an activation step prior to ligand binding and
signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly …

The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling

RT Böttcher, N Pollet, H Delius, C Niehrs - Nature cell biology, 2004 - nature.com
Fibroblast growth factors (FGFs) signal through high-affinity tyrosine kinase receptors to regulate
a diverse range of cellular processes, including cell growth, differentiation and migration…

Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation

…, R Ruppert, S Ussar, D Katsougkri, RT Böttcher… - Nature medicine, 2014 - nature.com
Kindlin-1 is an integrin tail binding protein that controls integrin activation. Mutations in the
FERMT-1 gene, which encodes for Kindlin-1, lead to Kindler syndrome in man, which is …

Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading

RT Böttcher, M Veelders, P Rombaut, J Faix… - Journal of Cell …, 2017 - rupress.org
Cell spreading requires the coupling of actin-driven membrane protrusion and integrin-mediated
adhesion to the extracellular matrix. The integrin-activating adaptor protein kindlin-2 …

Soluble uric acid inhibits β2 integrin–mediated neutrophil recruitment in innate immunity

…, Q Li, P Romagnani, RT Böttcher… - Blood, The Journal …, 2022 - ashpublications.org
Neutrophils are key players during host defense and sterile inflammation. Neutrophil dysfunction
is a characteristic feature of the acquired immunodeficiency during kidney disease. We …

[HTML][HTML] PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis

…, F Clapero, E Panieri, V Panero, RT Böttcher… - Nature …, 2016 - nature.com
Basolateral polymerization of cellular fibronectin (FN) into a meshwork drives endothelial cell
(EC) polarity and vascular remodelling. However, mechanisms coordinating α5β1 integrin-…

Profilin 1 is required for abscission during late cytokinesis of chondrocytes

RT Böttcher, S Wiesner, A Braun, R Wimmer… - The EMBO …, 2009 - embopress.org
Profilins are key factors for dynamic rearrangements of the actin cytoskeleton. However, the
functions of profilins in differentiated mammalian cells are uncertain because profilin …