Fibroblast growth factor signaling during early vertebrate development
RT Bottcher, C Niehrs - Endocrine reviews, 2005 - academic.oup.com
Fibroblast growth factors (FGFs) have been implicated in diverse cellular processes
including apoptosis, cell survival, chemotaxis, cell adhesion, migration, differentiation, and …
including apoptosis, cell survival, chemotaxis, cell adhesion, migration, differentiation, and …
Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail
RT Böttcher, C Stremmel, A Meves, H Meyer… - Nature cell …, 2012 - nature.com
Integrin functions are controlled by regulating their affinity for ligand, and by the efficient
recycling of intact integrins through endosomes. Here we demonstrate that the Kindlin-binding …
recycling of intact integrins through endosomes. Here we demonstrate that the Kindlin-binding …
[PDF][PDF] Migrating platelets are mechano-scavengers that collect and bundle bacteria
Blood platelets are critical for hemostasis and thrombosis and play diverse roles during immune
responses. Despite these versatile tasks in mammalian biology, their skills on a cellular …
responses. Despite these versatile tasks in mammalian biology, their skills on a cellular …
Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin
M Theodosiou, M Widmaier, RT Böttcher, E Rognoni… - Elife, 2016 - elifesciences.org
10.7554/eLife.10130.001 Integrins require an activation step prior to ligand binding and
signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly …
signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly …
The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling
RT Böttcher, N Pollet, H Delius, C Niehrs - Nature cell biology, 2004 - nature.com
Fibroblast growth factors (FGFs) signal through high-affinity tyrosine kinase receptors to regulate
a diverse range of cellular processes, including cell growth, differentiation and migration…
a diverse range of cellular processes, including cell growth, differentiation and migration…
Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation
…, R Ruppert, S Ussar, D Katsougkri, RT Böttcher… - Nature medicine, 2014 - nature.com
Kindlin-1 is an integrin tail binding protein that controls integrin activation. Mutations in the
FERMT-1 gene, which encodes for Kindlin-1, lead to Kindler syndrome in man, which is …
FERMT-1 gene, which encodes for Kindlin-1, lead to Kindler syndrome in man, which is …
Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading
RT Böttcher, M Veelders, P Rombaut, J Faix… - Journal of Cell …, 2017 - rupress.org
Cell spreading requires the coupling of actin-driven membrane protrusion and integrin-mediated
adhesion to the extracellular matrix. The integrin-activating adaptor protein kindlin-2 …
adhesion to the extracellular matrix. The integrin-activating adaptor protein kindlin-2 …
Soluble uric acid inhibits β2 integrin–mediated neutrophil recruitment in innate immunity
…, Q Li, P Romagnani, RT Böttcher… - Blood, The Journal …, 2022 - ashpublications.org
Neutrophils are key players during host defense and sterile inflammation. Neutrophil dysfunction
is a characteristic feature of the acquired immunodeficiency during kidney disease. We …
is a characteristic feature of the acquired immunodeficiency during kidney disease. We …
[HTML][HTML] PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis
…, F Clapero, E Panieri, V Panero, RT Böttcher… - Nature …, 2016 - nature.com
Basolateral polymerization of cellular fibronectin (FN) into a meshwork drives endothelial cell
(EC) polarity and vascular remodelling. However, mechanisms coordinating α5β1 integrin-…
(EC) polarity and vascular remodelling. However, mechanisms coordinating α5β1 integrin-…
Profilin 1 is required for abscission during late cytokinesis of chondrocytes
RT Böttcher, S Wiesner, A Braun, R Wimmer… - The EMBO …, 2009 - embopress.org
Profilins are key factors for dynamic rearrangements of the actin cytoskeleton. However, the
functions of profilins in differentiated mammalian cells are uncertain because profilin …
functions of profilins in differentiated mammalian cells are uncertain because profilin …