Emerging technologies allow the high-throughput profiling of metabolic status from a blood
specimen (metabolomics). We investigated whether metabolite profiles could predict the …

Background— Vitamin D receptors have a broad tissue distribution that includes vascular
smooth muscle, endothelium, and cardiomyocytes. A growing body of evidence suggests that …

Background Extreme obesity is recognized to be a risk factor for heart failure. It is unclear
whether overweight and lesser degrees of obesity also pose a risk. Methods We investigated …

Background— Visceral adipose tissue (VAT) compartments may confer increased metabolic
risk. The incremental utility of measuring both visceral and subcutaneous abdominal …

Background— Separate multivariable risk algorithms are commonly used to assess risk of
specific atherosclerotic cardiovascular disease (CVD) events, ie, coronary heart disease, …

Identification of key factors associated with the risk of developing cardiovascular disease
and quantification of this risk using multivariable prediction algorithms are among the major …

Background Heart failure is a major public health problem. Long-term trends in the incidence
of heart failure and survival after its onset in the community have not been characterized. …

Background— Various measures of arterial stiffness and wave reflection have been
proposed as cardiovascular risk markers. Prior studies have not assessed relations of a …

Objectives : The goal of this study was to determine whether aortic pulse wave velocity (aPWV)
improves prediction of cardiovascular disease (CVD) events beyond conventional risk …

ContextThe long-term risk for developing hypertension is best described by the lifetime risk
statistic. The lifetime risk for hypertension and trends in this risk over time are unknown.…