Background We observed a syndrome of intermittent fevers, early-onset lacunar strokes and
other neurovascular manifestations, livedoid rash, hepatosplenomegaly, and systemic …

Over 200,000 new prostate cancer cases are diagnosed in the United States each year,
accounting for more than 35% of all cancer cases affecting men, and resulting in 40,000 deaths …

It is fundamentally important that signaling gradients provide positional information to govern
morphogenesis of multicellular organisms. Morphogen gradients can generate different cell …

The use of CRISPR/Cas9 as a genome-editing tool in various model organisms has radically
changed targeted mutagenesis. Here, we present a high-throughput targeted mutagenesis …

Altered growth and function of synoviocytes, the intimal cells which line joint cavities and
tendon sheaths, occur in a number of skeletal diseases 1. Hyperplasia of synoviocytes is found …

Familial Mediterranean Fever at the Millennium Clinical Spec... : Medicine Familial
Mediterranean Fever at the Millennium Clinical Spectrum, Ancient Mutations, and a Survey of 100 …

RUNX1 is a member of the core-binding factor family of transcription factors and is indispensable
for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is one of the …

To gain insight into melanoma pathogenesis, we characterized an insertional mouse mutant,
TG3, that is predisposed to develop multiple melanomas 1 , 2 . Physical mapping identified …

Differential modifications of proliferating cell nuclear antigen (PCNA) determine DNA repair
pathways at stalled replication forks. In yeast, PCNA monoubiquitination by the ubiquitin …

The zebrafish is a popular model organism for studying development and disease, and
genetically modified zebrafish provide an essential tool for functional genomic studies. …