Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses
Macrophages play host to Leishmania major, a parasite that causes leishmaniasis in 500,000
people annually. Macrophage-expressed CD40, a costimulatory molecule 1 , induces …
people annually. Macrophage-expressed CD40, a costimulatory molecule 1 , induces …
[HTML][HTML] Diosgenin from Dioscorea bulbifera: Novel Hit for Treatment of Type II Diabetes Mellitus with Inhibitory Activity against α-Amylase and α-Glucosidase
…, A Asok, N Kumbhar, ML Shaikh, B Ramanamurthy… - PloS one, 2014 - journals.plos.org
Diabetes mellitus is a multifactorial metabolic disease characterized by post-prandial
hyperglycemia (PPHG). α-amylase and α-glucosidase inhibitors aim to explore novel therapeutic …
hyperglycemia (PPHG). α-amylase and α-glucosidase inhibitors aim to explore novel therapeutic …
[HTML][HTML] Potential dual role of eugenol in inhibiting advanced glycation end products in diabetes: proteomic and mechanistic insights
…, VS Dhaygude, ML Shaikh, RS Joshi, R Boppana… - Scientific reports, 2016 - nature.com
Medicinally important genus Ocimum harbors a vast pool of chemically diverse metabolites.
Current study aims at identifying anti-diabetic candidate compounds from Ocimum species. …
Current study aims at identifying anti-diabetic candidate compounds from Ocimum species. …
[PDF][PDF] Antidiabetic and antioxidant properties of copper nanoparticles synthesized by medicinal plant Dioscorea bulbifera
…, S Singh, ML Shaikh, B Ramanamurthy… - … of Nanomedicine & …, 2015 - researchgate.net
Background: Biological route for synthesis of copper nanoparticles (CuNPs) with therapeutic
potential is a major challenge. In this study, CuNPs were synthesized by D. bulbifera tuber …
potential is a major challenge. In this study, CuNPs were synthesized by D. bulbifera tuber …
Low plasma albumin levels are associated with increased plasma protein glycation and HbA1c in diabetes
…, AP Giri, KM Shelgikar, R Boppana… - Journal of proteome …, 2012 - ACS Publications
Albumin is one of the most abundant plasma proteins and is heavily glycated in diabetes. In
this study, we have addressed whether variation in the albumin levels influence glycation of …
this study, we have addressed whether variation in the albumin levels influence glycation of …
CD40 Signaling Is Impaired in L. major–infected Macrophages and Is Rescued by a p38MAPK Activator Establishing a Host-protective Memory T Cell Response
…, BN Joshi, N Jain, S Sawant, R Boppana… - The Journal of …, 2003 - rupress.org
Leishmania, a protozoan parasite, lives and multiplies as amastigote within macrophages. It
is proposed that the macrophage expressed CD40 interacts with CD40 ligand on T cells to …
is proposed that the macrophage expressed CD40 interacts with CD40 ligand on T cells to …
Vitexin alleviates non-alcoholic fatty liver disease by activating AMPK in high fat diet fed mice
S Inamdar, A Joshi, S Malik, R Boppana… - Biochemical and …, 2019 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a most common liver disorder characterized by
accumulation of fat in the liver and currently there is no approved treatment for it. Obesity and …
accumulation of fat in the liver and currently there is no approved treatment for it. Obesity and …
CCR6 signaling inhibits suppressor function of induced-Treg during gut inflammation
…, VR Mujeeb, S Srivastava, R Boppana… - Journal of …, 2018 - Elsevier
CCR6 is a G protein-coupled receptor (GPCR) that binds to a specific chemokine, CCL20.
The role of CCR6-CCL20 is very well studied in the migration of immune cells, but the non-…
The role of CCR6-CCL20 is very well studied in the migration of immune cells, but the non-…
[HTML][HTML] Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression
…, MV Vijayakumar, R Kumari, V Pandey, R Boppana… - Molecular cancer, 2010 - Springer
Background p53 is the most studied tumor suppressor and its overexpression may or may not
cause cell death depending upon the genetic background of the cells. p53 is degraded by …
cause cell death depending upon the genetic background of the cells. p53 is degraded by …
[HTML][HTML] Proteome wide reduction in AGE modification in streptozotocin induced diabetic mice by hydralazine mediated transglycation
…, SD Bhosale, ML Shaikh, HV Thulasiram, R Boppana… - Scientific reports, 2013 - nature.com
The non-enzymatic reaction between glucose and protein can be chemically reversed by
transglycation. Here we report the transglycation activity of hydralazine using a newly …
transglycation. Here we report the transglycation activity of hydralazine using a newly …