The tumor microenvironment of colorectal carcinoma is a complex community of genomically
altered cancer cells, nonneoplastic cells, and a diverse collection of microorganisms. Each …

CHROMOSOMAL translocations associated with malignancies often result in deregulated
expression of genes encoding transcription factors 1 . In human T-cell leukaemias such …

Lineage-survival oncogenes are activated by somatic DNA alterations in cancers arising
from the cell lineages in which these genes play a role in normal development 1 , 2 . Here we …

Transcription factor GATA‐1 is essential for red blood cell maturation and, therefore, for survival
of developing mouse embryos. GATA‐1 is also expressed in megakaryocytes, mast cells…

Despite the importance of blood platelets in health and disease, the mechanisms regulating
their formation within megakaryocytes are unknown. We generated mice lacking the …

Key molecular lesions in colorectal and other cancers cause β-catenin-dependent
transactivation of T cell factor (Tcf)-dependent genes. Disruption of this signal represents an …

Platelets are generated from megakaryocytes (MKs) in mammalian bone marrow (BM) by
mechanisms that remain poorly understood. Here we describe the use of multiphoton intravital …

Aberrant activation of the canonical WNT/β-catenin pathway occurs in almost all colorectal
cancers and contributes to their growth, invasion and survival 1 , 2 . Although dysregulated β-…

Megakaryocytes release mature platelets in a complex process. Platelets are known to be
released from intermediate structures, designated proplatelets, which are long, tubelike …

Cetuximab, an antibody directed against the epidermal growth factor receptor, is an effective
clinical therapy for patients with colorectal, head and neck, and non–small cell lung cancer, …