User profiles for Ramesh Utharala

Ramesh Utharala

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Cited by 1078

[HTML][HTML] Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics

N Shembekar, C Chaipan, R Utharala, CA Merten - Lab on a Chip, 2016 - pubs.rsc.org
Droplet-based microfluidics enables assays to be carried out at very high throughput (up to
thousands of samples per second) and enables researchers to work with very limited material…

Functional single-cell hybridoma screening using droplet-based microfluidics

BE Debs, R Utharala, IV Balyasnikova… - Proceedings of the …, 2012 - National Acad Sciences
Monoclonal antibodies can specifically bind or even inhibit drug targets and have hence
become the fastest growing class of human therapeutics. Although they can be screened for …

[HTML][HTML] A microfluidics platform for combinatorial drug screening on cancer biopsies

F Eduati, R Utharala, D Madhavan… - Nature …, 2018 - nature.com
Screening drugs on patient biopsies from solid tumours has immense potential, but is challenging
due to the small amount of available material. To address this, we present here a plug-…

Microfluidics as an enabling technology for personalized cancer therapy

L Mathur, M Ballinger, R Utharala, CA Merten - Small, 2020 - Wiley Online Library
Tailoring patient‐specific treatments for cancer is necessary in order to achieve optimal results
but requires new diagnostic approaches at affordable prices. Microfluidics has immense …

A microfluidic Braille valve platform for on-demand production, combinatorial screening and sorting of chemically distinct droplets

R Utharala, A Grab, V Vafaizadeh, N Peschke… - Nature protocols, 2022 - nature.com
Droplet microfluidics is a powerful tool for a variety of biological applications including single-cell
genetics, antibody discovery and directed evolution. All these applications make use of …

A versatile, low-cost, multiway microfluidic sorter for droplets, cells, and embryos

R Utharala, Q Tseng, EEM Furlong… - Analytical …, 2018 - ACS Publications
Partitioning and sorting particles, including molecules, cells and organisms, is an essential
prerequisite for a diverse range of applications. Here, we describe a very economical …

[PDF][PDF] iSort enables automated complex microfluidic droplet sorting in an effort to democratize technology

J Panwar, R Utharala, L Fennelly, D Frenzel… - Cell Reports …, 2023 - cell.com
Fluorescence-activated droplet sorting (FADS) is a widely used microfluidic technique for
high-throughput screening. However, it requires highly trained specialists to determine optimal …

Rapid identification of optimal drug combinations for personalized cancer therapy using microfluidics

F Eduati, R Utharala, D Madhavan, UP Neumann… - bioRxiv, 2016 - biorxiv.org
Functional screening of live patient cancer cells holds great potential for personalized medicine
and allows to overcome the limited translatability of results from existing in-vitro and ex-…

Automated droplet manipulation in microfluidic systems

J Panwar, R Utharala, C Merten, L Fennelly - 2023 - infoscience.epfl.ch
Disclosed herein is a method of operating a microfluidic system, a microfluidic system for
manipulating sample objects, and a control system for operating a microfluidic system. The …

Gregory Stephanopoulos and colleagues reply to Screening cellular metabolic activity

B El Debs, R Utharala, CA Merten - Nature biotechnology, 2014 - nature.com
El Debs and Merten 1 contend that “this approach”(ie, of an integrated microfluidic device
described in our paper 2 allowing the encapsulation of cells into droplets, which can be …