User profiles for Ramesh Utharala
Ramesh UtharalaEMBL Verified email at embl.de Cited by 1078 |
[HTML][HTML] Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics
N Shembekar, C Chaipan, R Utharala, CA Merten - Lab on a Chip, 2016 - pubs.rsc.org
Droplet-based microfluidics enables assays to be carried out at very high throughput (up to
thousands of samples per second) and enables researchers to work with very limited material…
thousands of samples per second) and enables researchers to work with very limited material…
Functional single-cell hybridoma screening using droplet-based microfluidics
BE Debs, R Utharala, IV Balyasnikova… - Proceedings of the …, 2012 - National Acad Sciences
Monoclonal antibodies can specifically bind or even inhibit drug targets and have hence
become the fastest growing class of human therapeutics. Although they can be screened for …
become the fastest growing class of human therapeutics. Although they can be screened for …
[HTML][HTML] A microfluidics platform for combinatorial drug screening on cancer biopsies
F Eduati, R Utharala, D Madhavan… - Nature …, 2018 - nature.com
Screening drugs on patient biopsies from solid tumours has immense potential, but is challenging
due to the small amount of available material. To address this, we present here a plug-…
due to the small amount of available material. To address this, we present here a plug-…
Microfluidics as an enabling technology for personalized cancer therapy
L Mathur, M Ballinger, R Utharala, CA Merten - Small, 2020 - Wiley Online Library
Tailoring patient‐specific treatments for cancer is necessary in order to achieve optimal results
but requires new diagnostic approaches at affordable prices. Microfluidics has immense …
but requires new diagnostic approaches at affordable prices. Microfluidics has immense …
A microfluidic Braille valve platform for on-demand production, combinatorial screening and sorting of chemically distinct droplets
R Utharala, A Grab, V Vafaizadeh, N Peschke… - Nature protocols, 2022 - nature.com
Droplet microfluidics is a powerful tool for a variety of biological applications including single-cell
genetics, antibody discovery and directed evolution. All these applications make use of …
genetics, antibody discovery and directed evolution. All these applications make use of …
A versatile, low-cost, multiway microfluidic sorter for droplets, cells, and embryos
Partitioning and sorting particles, including molecules, cells and organisms, is an essential
prerequisite for a diverse range of applications. Here, we describe a very economical …
prerequisite for a diverse range of applications. Here, we describe a very economical …
[PDF][PDF] iSort enables automated complex microfluidic droplet sorting in an effort to democratize technology
J Panwar, R Utharala, L Fennelly, D Frenzel… - Cell Reports …, 2023 - cell.com
Fluorescence-activated droplet sorting (FADS) is a widely used microfluidic technique for
high-throughput screening. However, it requires highly trained specialists to determine optimal …
high-throughput screening. However, it requires highly trained specialists to determine optimal …
Rapid identification of optimal drug combinations for personalized cancer therapy using microfluidics
F Eduati, R Utharala, D Madhavan, UP Neumann… - bioRxiv, 2016 - biorxiv.org
Functional screening of live patient cancer cells holds great potential for personalized medicine
and allows to overcome the limited translatability of results from existing in-vitro and ex-…
and allows to overcome the limited translatability of results from existing in-vitro and ex-…
Automated droplet manipulation in microfluidic systems
J Panwar, R Utharala, C Merten, L Fennelly - 2023 - infoscience.epfl.ch
Disclosed herein is a method of operating a microfluidic system, a microfluidic system for
manipulating sample objects, and a control system for operating a microfluidic system. The …
manipulating sample objects, and a control system for operating a microfluidic system. The …
Gregory Stephanopoulos and colleagues reply to Screening cellular metabolic activity
B El Debs, R Utharala, CA Merten - Nature biotechnology, 2014 - nature.com
El Debs and Merten 1 contend that “this approach”(ie, of an integrated microfluidic device
described in our paper 2 allowing the encapsulation of cells into droplets, which can be …
described in our paper 2 allowing the encapsulation of cells into droplets, which can be …