Obsessive-compulsive disorder (OCD) is an anxiety-spectrum disorder characterized by
persistent intrusive thoughts (obsessions) and repetitive actions (compulsions). Dysfunction of …

The clinical efficacy and safety of a drug is determined by its activity profile across many
proteins in the proteome. However, designing drugs with a specific multi-target profile is both …

SHANK3 is a synaptic scaffolding protein enriched in the postsynaptic density (PSD) of
excitatory synapses. Small microdeletions and point mutations in SHANK3 have been identified …

There is considerable interest in screening ultralarge chemical libraries for ligand discovery,
both empirically and computationally 1 , 2 , 3 – 4 . Efforts have focused on readily …

Dysregulation of brain serotonin (5-HT) neurotransmission is thought to underlie mental
conditions as diverse as depression, anxiety disorders, bipolar disorder, autism, and …

Besides their role in desensitization, β-arrestin 1 and 2 promote the formation of signaling
complexes allowing G protein-coupled receptors (GPCR) to signal independently from G …

Quetiapine is an atypical antipsychotic drug that is also US FDA approved for treating bipolar
depression, albeit by an unknown mechanism. To discover the potential mechanism for this …

As discussion of stress and stress-related disorders rapidly extends beyond the brain, gut
microbiota have emerged as a promising contributor to individual differences in the risk of …

The functions of synapsins were examined by characterizing the phenotype of mice in which
all three synapsin genes were knocked out. Although these triple knock-out mice were …

Human neuroimaging studies suggest that aberrant neural connectivity underlies
behavioural deficits in autism spectrum disorders (ASDs), but the molecular and neural circuit …