The pediatric immune deficiency X-linked proliferative disease-2 (XLP-2) is a unique
disease, with patients presenting with either hemophagocytic lymphohistiocytosis (HLH) or …

Basophil granulocytes and mast cells are recognized for their roles in immunity and are central
effectors of diverse immunological disorders. Despite their similarities, there is emerging …

Interleukin 4 (IL-4) is a critical cytokine implicated with T H 2 immune reactions, which are
linked to pathologic conditions of allergic diseases. In that context, the initiation of T H 2 …

BH3-mimetics are small molecule inhibitors that neutralize the function of anti-apoptotic BCL-2
family members. BH3-mimetics have recently gained a lot of popularity in oncology …

2. Spergel JM. Epidemiology of atopic dermatitis and atopic march in children. Immunol Allergy
Clin North Am 2010; 30: 269-80. 3. Werfel T, Allam JP, Biedermann T, Eyerich K, Gilles S, …

Granulocytes are central players of the immune system and, once activated, a tightly controlled
balance between effector functions and cell removal by apoptosis guarantees maximal …

Recent data suggests that LPS stimulation can trigger inflammasome activation through a
TNFR2/TNF/TNFR1 mediated loop in xiap −/− macrophages. Yet, the direct role TNFR2-…

… Spilgies, # 1 Stefanie Rufli, 1 Ramona Reinhart, 2 Lazaros Vasilikos, 1 Monica Yabal, 3
Erika Owsley, 4 Philipp J. Jost, 3 Rebecca A. Marsh, 4 Harald Wajant, 5 Mark D. …

Background Thymic stromal lymphopoietin (TSLP) and eosinophils are prominent components
of allergic inflammation. Therefore, we sought to determine whether TSLP could activate …