Crohn’s disease (CD) is a chronic transmural inflammation of intestinal segments caused by
dysregulated interaction between microbiome and gut immune system. Here, we profile, via …

Aging is a main risk factor for osteoarthritis (OA). FoxO transcription factors protect against
cellular and organismal aging, and FoxO expression in cartilage is reduced with aging and in …

To allow efficient transcript/gene detection, highly abundant ribosomal RNAs (rRNA) are
generally removed from total RNA either by positive polyA+ selection or by rRNA depletion (…

Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood
cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced …

Innate lymphoid cells (ILCs) are tissue-resident lymphocytes categorized on the basis of
their core regulatory programs and the expression of signature cytokines. Human ILC3s that …

Objective Osteoarthritis (OA) is the most prevalent joint disease. As disease-modifying
therapies are not available, novel therapeutic targets need to be discovered and prioritized for …

Visceral white adipose tissue (vWAT) expands and undergoes extensive remodeling during
diet-induced obesity. Much is known about the contribution of various stromal vascular cells …

Meniscus tears are common knee injuries and a major osteoarthritis (OA) risk factor.
Knowledge gaps that limit the development of therapies for meniscus injury and degeneration …

Nuclear pore complexes (NPCs) form gateways for material transfer across the nuclear envelope
of eukaryotic cells. Disordered proteins, rich in phenylalanine-glycine repeat motifs (FG-…

Mechanosensitive channels, inner membrane proteins of bacteria, open and close in response
to mechanical stimuli such as changes in membrane tension during osmotic stress. In …