The V (D) J recombination activation gene RAG-1 was isolated on the basis of its ability to
activate V (D) J recombination on an artificial substrate in fibroblasts. This property and the …

Granulocytes and monocytes/macrophages of the myeloid lineage are the chief cellular
agents of innate immunity. Here, we have examined the inflammatory response in mice with …

The transcriptional response to lowered oxygen levels is mediated by the hypoxia-inducible
transcription factor (HIF-1), a heterodimer consisting of the constitutively expressed aryl …

Hypoxia-inducible factors (HIFs) are broadly expressed in human cancers, and HIF1α and
HIF2α were previously suspected to promote tumour progression through largely overlapping …

The hypoxic response is an ancient stress response triggered by low ambient oxygen (O 2 )
(ref. 1 ) and controlled by hypoxia-inducible transcription factor-1 (HIF-1), whose α subunit is …

THE principal substrate for the insulin and insulin-like growth factor-1 (IGF-1) receptors is
the cytoplasmic protein insulin-receptor substrate-1 (IRS-l/pplSS) 1–7 . After tyrosine …

Development of hypoxic regions is an indicator of poor prognosis in many tumors. Here, we
demonstrate that HIF1α, the direct effector of hypoxia, partly through increases in SDF1α, …

In glioblastoma-derived cell lines, PTEN does not significantly alter apoptotic sensitivity or
cause complete inhibition of DNA synthesis. However, in these cell lines PTEN regulates …

Hypoxia has been proposed as an important microenvironmental factor in the development
of tissue fibrosis; however, the underlying mechanisms are not well defined. To examine the …

The hypoxic response in cells and tissues is mediated by the family of hypoxia-inducible
factor (HIF) transcription factors; these play an integral role in the metabolic changes that drive …