There has been an increasing interest in understanding how the mechanical properties of
the microenvironment influence stem cell fate. We describe studies of the proliferation and …

Three dimensional, self-assembled organoids that recapitulate key developmental and
organizational events during embryogenesis have proven transformative for the study of human …

10.7554/eLife.44530.001 Two-dimensional (2D) human skeletal muscle fiber cultures are ill-equipped
to support the contractile properties of maturing muscle fibers. This limits their …

The embryonic neuroepithelium gives rise to the entire central nervous system in vivo,
making it an important tissue for developmental studies and a prospective cell source for …

Over the last decade, scientists have begun to model CNS development, function, and
disease in vitro using human pluripotent stem cell (hPSC)-derived organoids. Using traditional …

Three-dimensional organoids derived from human pluripotent stem cell (hPSC) derivatives
have become widely used in vitro models for studying development and disease. Their ability …

We describe a method for creating alginate hydrogels with adjustable degradation rates that
can be used as scaffolds for stem cells. Alginate hydrogels have been widely tested as three…

Neurogenesis in the adult hippocampus involves activation of quiescent neural stem cells (NSCs)
to yield transiently amplifying NSCs, progenitors, and, ultimately, neurons that affect …

Advances within in vitro biological system complexity have enabled new possibilities for the
“Organs-on-a-Chip” field. Microphysiological systems (MPS) as such incorporate …

Colinear HOX expression during hindbrain and spinal cord development diversifies and
assigns regional neural phenotypes to discrete rhombomeric and vertebral domains. Despite …