User profiles for Randolph S. Ashton

Randolph S. Ashton

Dept. of Biomedical Engineering, UW Madison & Wisconsin Institute for Discovery
Verified email at wisc.edu
Cited by 2982

The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells

A Banerjee, M Arha, S Choudhary, RS Ashton… - Biomaterials, 2009 - Elsevier
There has been an increasing interest in understanding how the mechanical properties of
the microenvironment influence stem cell fate. We describe studies of the proliferation and …

Scaffolds based on degradable alginate hydrogels and poly (lactide-co-glycolide) microspheres for stem cell culture

RS Ashton, A Banerjee, S Punyani, DV Schaffer… - Biomaterials, 2007 - Elsevier
We describe a method for creating alginate hydrogels with adjustable degradation rates that
can be used as scaffolds for stem cells. Alginate hydrogels have been widely tested as three…

Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling

RS Ashton, A Conway, C Pangarkar, J Bergen… - Nature …, 2012 - nature.com
Neurogenesis in the adult hippocampus involves activation of quiescent neural stem cells (NSCs)
to yield transiently amplifying NSCs, progenitors, and, ultimately, neurons that affect …

[PDF][PDF] Deterministic HOX patterning in human pluripotent stem cell-derived neuroectoderm

…, MC Estevez-Silva, ER Chapman, JJ Coon, RS Ashton - Stem cell reports, 2015 - cell.com
Colinear HOX expression during hindbrain and spinal cord development diversifies and
assigns regional neural phenotypes to discrete rhombomeric and vertebral domains. Despite …

Micropattern width dependent sarcomere development in human ESC-derived cardiomyocytes

…, J Sha, GT Knight, SA Chindhy, TJ Kamp, RS Ashton… - Biomaterials, 2014 - Elsevier
In this study, human embryonic stem cell-derived cardiomyocytes were seeded onto controlled
two-dimensional micropatterned features, and an improvement in sarcomere formation …

Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis

…, R Moore, R Sharma, P Pirrotte, RS Ashton… - Nature …, 2023 - nature.com
Genes involved in synaptic function are enriched among those with autism spectrum disorder
(ASD)-associated rare genetic variants. Dysregulated cortical neurogenesis has been …

The case for applying tissue engineering methodologies to instruct human organoid morphogenesis

CR Marti-Figueroa, RS Ashton - Acta biomaterialia, 2017 - Elsevier
Three-dimensional organoids derived from human pluripotent stem cell (hPSC) derivatives
have become widely used in vitro models for studying development and disease. Their ability …

[HTML][HTML] New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop

C Mahony, RS Ashton, B Birk, AR Boobis, T Cull… - Regulatory Toxicology …, 2020 - Elsevier
The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened
a ‘Blue Sky Workshop’ on new ideas for non-animal approaches to predict repeated-dose …

Micropatterned substrates with physiological stiffness promote cell maturation and Pompe disease phenotype in human induced pluripotent stem cell‐derived skeletal …

…, BN Napiwocki, A Stempien, RS Ashton… - Biotechnology and …, 2019 - Wiley Online Library
Recent advances in bioengineering have enabled cell culture systems that more closely
mimic the native cellular environment. Here, we demonstrated that human induced pluripotent …

Bioengineering tissue morphogenesis and function in human neural organoids

NJ Fedorchak, N Iyer, RS Ashton - Seminars in cell & developmental …, 2021 - Elsevier
Over the last decade, scientists have begun to model CNS development, function, and
disease in vitro using human pluripotent stem cell (hPSC)-derived organoids. Using traditional …